Although psoriasis and bullous diseases are considered to be completely different disease entities, the literature has reported a few cases of psoriasis associated with bullous diseases, most of which are bullous pemphigoid. In limited cases, pemphigus foliaceus has also been reported in association with psoriasis. In most of them, pemphigus lesions usually developed on an untreated patient wit...

BACKGROUND Progressive macular hypomelanosis (PMH) is a disease of unclear etiology. Propionbacterium acnes (P. acnes) was claimed to be an etiological factor. OBJECTIVES The purpose of this study was to document the clinicopathological features of PMH in Egyptian patients and to evaluate the therapeutic outcome. METHODS Patients with clinical features of PMH were recruited. Wood's lamp exa...

BACKGROUND Phototherapy is one of the most effective treatment options in vitiligo. Targeted phototherapy devices are becoming more popular as they offer a lot of advantages over the conventional whole-body phototherapy units. AIMS AND OBJECTIVES The present study was conducted to assess the efficacy and safety of a targeted narrowband ultraviolet B (NBUVB) device in vitiligo. MATERIALS AND...

Background: Targeted UVB phototherapy currently ranks among the most effective treatment options in localized vitiligo. Purpose: The study aims to assess the efficacy of Targeted NBUVB monotherapy in childhood vitiligo involving less than 10% body surface area. Methods: Thirty-five children with vitiligo, less than 15-years of age were treated with Targeted NBUVB device twice weekly till comple...

Folate plays an important role in metabolism and its deficiency can lead to cardiovascular problems or carcinogenesis. Some studies show that narrow band UVB (NBUVB) causes folate deficiency by photolysis , while others have different opinions or even the contrary. With regard to paradoxes in this context, we decided to study the effect of NBUVB on folate levels in patients with dermatologic di...

TO THE EDITOR Research and media have highlighted carcinogenic dangers of tanning bed exposure. Skin cancer risk of other sources of artificial UV radiation has been discussed, but not researched in detail. UV nail lamps, a source of artificial UV radiation (UVR), are increasingly used for professional and personal nail techniques. UV nail lamps contain either fluorescent bulbs or lightemitting...

Background: Vitiligo is a pigmentation disorder of the skin characterized by the loss of melanocytes through different mechanisms. Narrow band UVB (NBUVB) is a safe and effective treatment for vitiligo that acts by inducing the synthesis of cytokines involved in melanogenesis. NBUVB appears to be involved in the treatment of vitiligo by increasing the synthesis of vitamin D, which prevents the ...

Vitiligo is a polygenic acquired skin disorder resulting from the destruction of melanocytes in epidermal cells. Conventional therapeutic options include covering agents, topical corticosteroids, immunomodulators, phototherapy with psolaren ultraviolet A (PUVA) and narrowband B (NBUVB). However, successful repigmentation these modalities expected only half patients. This study aimed to compare ...

BACKGROUND Matrix metalloproteinases (MMPs), which show a significant ability to cleave the components of extracellular matrix, and tissue inhibitors of metalloproteinases (TIMPs), which slow down the activity of those enzymes, may be implicated in the pathogenesis and spread of psoriatic disease. This study aims to analyze plasma levels of MMP-2 and TIMP-2 in plaque psoriasis patients before a...