2 were 2.23 (95% confidence interval, 1.34-3.70) times as likely to be aware of EBPs as those in group 1 in treating HSV stromal keratitis. Clinicians in group 3 were 2.92 (95% confidence interval, 1.70-5.01) and 2.27 (95% confidence interval, 1.29-3.98) times as likely to be aware of EBPs as their group 1 counterparts in treating HSV stromal keratitis and preventing recurrent HSV stromal kerat...

PURPOSE To report surgical therapies for corneal perforations in a tertiary referral hospital. METHODS Thirty-one eyes of 31 patients (aged 62.4±18.3 years) with surgically treated corneal perforations from January 2002 to July 2013 were included in this study. Demographic data such as cause of corneal perforation, surgical procedures, and visual outcomes were retrospectively analyzed. RESU...

For the purpose of determining the effect of levamisole on cell-mediated immunity of patients with herpetic stromal keratitis, the response of peripheral lymphocytes to three mitogens (PHA, Con A and PWM) was examined in a total of 19 cases of herpetic stromal keratitis (16 effective cases) including 12 patients undergoing levamisole administration. As controls, a similar study was made on 35 h...

BACKGROUND Herpetic necrotizing retinitis is a well-recognized entity. A few cases of herpetic non-necrotizing retinitis were previously reported. FINDINGS We retrospectively report two cases of herpetic non-necrotizing retinopathy with a long follow-up. A 19-year-old woman presented with a bilateral diffuse occlusive retinal vasculitis, peripheral neovascularization, and no signs of retinal ...

PURPOSE A dipeptide prodrug of the antiviral nucleoside acyclovir (ACV), val-val-ACV (VVACV), was evaluated in vivo as a potential drug candidate for improving antiviral efficacy against herpetic epithelial and stromal keratitis. METHODS The effect of 1% VVACV on epithelial keratitis induced by inoculation of HSV-1 strain McKrae (25 microL of 10(5) plaque-forming units [PFU]) in the scarified...

BACKGROUND Microsporidial keratitis is a rare cause of stromal keratitis. We present a series of five cases of microsporidial keratitis from a single centre in southern India with microbiologic and histopathologic features. CASE PRESENTATION Patient charts of five cases of microsporidial stromal keratitis diagnosed between January 2002 and June 2004 were reviewed retrospectively for clinical ...

Inflammation of the corneal stroma (stromal keratitis) is a serious complication of infection with the nematode parasite Onchocerca volvulus. Because stromal keratitis is believed to be immunologically mediated in humans, we used a murine model to examine the role of T cells and T helper cell cytokines in the immunopathogenesis of these eye lesions. BALB/c mice immunized subcutaneously and inje...

Necrotizing scleritis is an immune-mediated ocular inflammatory process, characterized by an area of avascular necrosis and a profound inflammation of the sclera and episclera. Necrotizing scleritis and its association with peripheral ulcerative keratitis--necrotizing sclerokeratitis (NS)--represents a serious threat for vision and eye integrity, evolves very fast if untreated, and its finding ...

BACKGROUND We report a case of necrotizing keratitis caused by acyclovir (ACV)-resistant herpes simplex virus (HSV) with a clinical appearance similar to a previous fungal keratitis infection. METHODS Observational case report. RESULTS Penetrating keratoplasty was performed in the left eye with a history of herpetic keratitis that resolved with periodic treatment with ACV ointment and a top...