The increasing amount of highly effective treatment options in relapsing forms of multiple sclerosis (MS) requires innovative clinical trial design strategies. These strategies may encompass the application of adaptive designs as well as the adoption of innovative primary outcome measurements. The offered advantages would include, among others, shorter study follow-up periods and reduction in t...

Abstract Most message passing neural networks (MPNNs) are widely used for assortative network representation learning under the assumption of homophily between connected nodes. However, this fundamental is inconsistent with heterophily disassortative (DNs) in many real-world applications. Therefore, we propose a novel MPNN called NEDA based on neighborhood expansion (DNRL). Specifically, our fi...

Changing in the production of anticancer drugs (vinblastine and vincristine) Catharanthus roseus (L.) G. Don by potassium ascorbic acid treatments | Neda Sahi, Akbar Mostajeran, Mustafa Ghanadian Agricultural Journals

BACKGROUND Subcutaneous peginterferon beta-1a provided clinical benefits at Year 1 (placebo-controlled period) of the 2-Year Phase 3 ADVANCE study in relapsing-remitting multiple sclerosis (RRMS). Here we report the effect of peginterferon beta-1a on brain magnetic resonance imaging (MRI) lesions, and no evidence of disease activity (NEDA; absence of clinical [relapses and 12-week confirmed dis...

The best way to develop a unique identity for the National Education Debate Association (NEDA) is to debate propositions distinct from National Debate Tournament (NDT) and the Cross Examination Debate Association (CEDA). A neglected area of debate includes propositions temporally framed in the past. Yet, the present propositional categories of fact, velue, and policy can explicitly incorporate ...

Pro-opiomelanocortin (POMC) is processed to adrenocorticotropic hormone (ACTH) and beta-lipotropin in corticotropes of the anterior lobe, and to alpha-melanocyte-stimulating hormone (alpha-MSH) and beta-endorphin in melanotropes of the intermediate lobe (IL) of the pituitary gland. While ACTH secretion is predominantly under the stimulatory influence of the hypothalamic factors, hormone secreti...

Background: There are still few prospective longitudinal studies of DMT in MS that show long-lasting effects. Methods: The data of longitudinal observation for 15 years on a group of 69 MS patients constantly receiving glatiramer acetate (GA) are presented. Results: The increase in relapse rate and EDSS progression were associated in a subgroup of patients with the presence of at least one rela...

Shahram Jamali1, Neda Alipasandi2,*, and Bita Alipasandi3 1Computer Engineering Department, University of Mohaghegh Ardabili, Ardabil, Iran 2Sama technical and vocational training college, Islamic Azad University, Ardabil Branch, Ardabil, Iran 3Young Researchers and Elite Club, Ardabil Branch, Islamic Azad University, Ardabil, Iran *Corresponding Author’ Information: Tel.: +98-45-33361902, E-ma...

to evaluate of rice genotypes in various modified systems, an experiment was carried out as split plot in randomized complete blocks design with four replications at neka region, mazandaran province, iran in 2011-2012. cropping systems were chosen as main plots including conventional, improved and system of rice intensification (sri) and genotypes as sub plots including: sang tarom, hashemi tar...