introduction: osteosarcoma is the most common primary bone tumor in children and young adults and appropriate chemotherapy can increase limb sparing and overall survival. yet, the toxicity of chemotherapy regimens including mtx can be life threatening. therefore; we tried another chemotherapy regimen for these patients. method and materials: we investigated 15 patients aged 15 to 40 years old a...

background: osteosarcoma is the most common bone sarcoma, and the third most common malignancy in children and adolescents. before 1970, amputation was the sole treatment. eighty percent of patients died from metastatic diseases, most commonly in the lungs. over the past three decades, effective neoadjuvant (preoperative) and adjuvant (postoperative) chemotherapy protocols have improved the abi...

tumor size seems to be a determinant in the prognosis of early cervical cancer. patients with tumor size greater than 4 cm (bulky) in diameter have worse outcome.' the purpose of this study was to compare the efficacy of preoperative combined chemoradiation and neoadjuvant chemotherapy (narc) programs followed by radical hysterectomy in stage ib - lib bulky cervical cancer. from september ...

introduction: breast cancer is the most common cancer and the second cause of death in women. it is essential to have the highest level of confidence in axillary staging assessment. many surgeons and pathologists believe that fewer lymph nodes are present in axillary dissection specimens of women treated by neoadjuvant chemotherapy. consequently, the purpose of this study was to compare the lym...

ticular, represent novel therapeutic approaches in the attempt to reverse disease progression and to cure patients in the long term. The latest advances in these fields raise hope for many patients. Specialists in transfusion medicine are encouraged to get more involved to help improving the practice and standardization of cellular therapies such as the so-called advanced therapeutical medicina...

A variety of strategies has been developed to assure safety of hemotherapy. Such strategies aim in particular at avoiding transfusion-transmitted infections. Safety of hemotherapy requires – in addition to safety of transfusion from infections – tolerance of the recipient towards the blood component to be transfused and tolerance of the blood component to be transfused towards the recipient, i....

introduction: early diagnosis and appropriate treatment is required in esophageal cancer due to its invasive nature. the aim of this study was to evaluate early post-esophagectomy complications in patients with esophageal cancer who received neoadjuvant chemoradiotherapy (nacr).   materials and methods: this randomized clinical trial was carried out between 2009 and 2011. patients with lower-th...

1Department of Hematology, Hospital del Mar, Barcelona, Spain; 2Department of Hemotherapy and Hemostasis, Hospital Clínic, Barcelona, Spain; 3Department of Hematology, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; 4Department of Hematology and Oncology, Hospital Clínico, Valencia, Spain; 5Department of Hematology, Hospital Morales Messeguer, Murcia...

background: in recent years, neoadjuvant chemoradiation and subsequent surgical resection with total mesorectal excision has been shown to increase local control with decreased toxicity. neoadjuvant chemoradiotherapy is the standard treatment for locally advanced rectal cancer. in this study we evaluated the efficacy a cox-2 inhibitor on pathologic response, sphincter preservation and acute tox...