BACKGROUND Children with neonatal diabetes often present with diabetic ketoacidosis and hence are at risk of cerebral oedema and subsequent long-term neurological deficits. These complications are difficult to identify because neurological features can also occur as a result of the specific genetic aetiology causing neonatal diabetes. CASE REPORTS We report two cases of neonatal diabetes wher...

Background: Gestational diabetes is one of the most common complications of pregnancy that has several effects on mother and baby. Objectives: The aim of this study was to examine the prevalence as well as maternal and neonatal outcomes in women with gestational diabetes. Methods: This descriptive comparative study was carried out on all pregnant women who underwent 75 g glucose test and refe...

BACKGROUND Patients with permanent neonatal diabetes usually present within the first three months of life and require insulin treatment. In most, the cause is unknown. Because ATP-sensitive potassium (K(ATP)) channels mediate glucose-stimulated insulin secretion from the pancreatic beta cells, we hypothesized that activating mutations in the gene encoding the Kir6.2 subunit of this channel (KC...

BACKGROUND Neonatal diabetes mellitus is a rare condition. CASE CHARACTERISTICS A small for gestational age male, presented with neonatal onset diabetes mellitus, duodenal atresia, annular pancreas and gall bladder hypoplasia. OBSERVATION Observation: A novel homozygous mutation p.K163R (c.488A>G) in the PDX1 gene was found. Parents were heterozygous for the same. MESSAGE This case highli...

BACKGROUND The purpose of this study was to evaluate maternal and neonatal outcomes in Korean women with type 1 diabetes and type 2 diabetes. METHODS We performed a retrospective survey of 163 pregnancies in women with type 1 diabetes (n=13) and type 2 diabetes (n=150) treated from 2003 to 2010 at Cheil General Hospital & Women's Healthcare Center, Korea. We compared maternal characteristics ...

introductio n: gestational diabetes is a medical condition that can lead to adverse outcomes of pregnancy. in this regard, the best way to reduce symptoms in patients, is to educate. this study was to determine the effect of face to face training and booklet on the consequences of maternal and fetal - neonatal diabetes in pregnancy.    method : the study is randomized controlled clinical trial ...

BACKGROUND Neonatal diabetes has not been previously studied in Ukraine. We investigated the genetic etiology in patients with onset of diabetes during the first 9 months of life. METHODS We established a Pediatric Diabetes Register to identify patients diagnosed with diabetes before 9 months of age. Genetic testing was undertaken for 42 patients with permanent or transient diabetes diagnosed ...

Since the discovery of the KATP channel in 1983, numerous studies have revealed its physiological functions. The KATP channel is expressed in various organs, including the pancreas, brain and skeletal muscles. It functions as a "metabolic sensor" that converts the metabolic status to electrical activity. In pancreatic beta-cells, the KATP channel regulates the secretion of insulin by sensing a ...