BACKGROUND The use of neonatal screening for cystic fibrosis is widely debated in the United Kingdom and elsewhere, but the evidence available to inform policy is limited. This paper explores the cost-effectiveness of adding screening for cystic fibrosis to an existing routine neonatal screening programme for congenital hypothyroidism and phenylketonuria, under alternative scenarios and assumpt...

Tyrosinemia resulting from administration of protein-dense infant diets was detected by newborn screening in two infants. Change of formula resulted in rapid resolution of the hypertyrosinemia. These cases identify nonstandard infant diets as a benign and reversible cause of tyrosinemia and a potential cause of positive newborn phenylketonuria screening.

BACKGROUND State newborn screening (NBS) programs are considering the storage and use of NBS blood samples for research. However, no systematic assessment of parents' attitudes exists. METHODS We conducted an Internet-based survey of a nationally representative parent sample. We examined parents' willingness (1) to permit use of their children's NBS samples for research with/without their per...

OBJECTIVE To determine whether there was increased stress and impact on the family for mothers of infants whose screening results and subsequent diagnostic findings indicated hearing loss (HL) and mothers of infants with a positive screening result who subsequently pass the rescreening (false-positive group), compared with mothers of infants who pass the initial screening (control group), when ...

Introduction Though based firmly on the "old fashioned" disease of phenylketonuria, whole population blood based neonatal screening is a technique with many potential uses. Most never enter general service despite their technical feasibility, reflecting mainly the perceived balance between costs and benefits. For historical reasons there is an underlying assumption that neonatal screening shoul...

About 30% of children with elevated TSH levels during neonatal screening have a transient form of disorder. On the other hand, it has been reported that subclinical hypothyroidism persists in late childhood in about 30% of children found to be false-positive during neonatal screening. The aim of this study was to determine whether transient thyroid dysfunction and subclinical hypothyroidism det...

background: recto-vaginal colonization of group b streptococcus (gbs) has been known as an important issue in mother and newborn’s health, which is getting frequent in developing countries. screening test have been introduced and utilized in many countries and is recommended by many researchers. however, due to lack of information in prevalence of gbs, especially in iran, there are doubts and c...