Increased intakes of protein have been shown to reduce kidney calcification (nephrocalcinosis) in female rats. Two questions were addressed in the present study. First, can protein-induced inhibition of nephrocalcinosis be demonstrated when the diets used are balanced for calcium, magnesium and phosphorus in the added protein? Second, can the protein effect be explained by the frequently observ...

BACKGROUND Nephrocalcinosis, characterized by intratubular and/or parenchymal deposition of calcium phosphate and calcium oxalate crystals, is frequently seen in renal allograft biopsies; however, the clinical consequence of this histologic finding remains unknown. Kidney transplant recipients with good allograft function usually demonstrate improvement in biochemical parameters; however, persi...

Male Wistar-strain rats which had been fed a glycolic-acid diet developed severe nephrocalcinosis with urinary calculi within 4 weeks. Rats fed the same diet with citrate salts added had, however, either slight or no nephrocalcinosis without any stones in the urinary system. Nephrocalcinosis intermediate between those in the citrate groups and the glycolic-acid group, with some urinary calculi,...

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare tubulopathy characterized by renal loss of calcium magnesium leading to progressive failure. The disorder caused variants the tight junction proteins claudin-16 -19. While rare, this causes significant burden patients based on its clinical manifestations various electrolyte abnormalities, nephrocalcinosis, early ...

INTRODUCTION Nephrocalcinosis consists of the deposition of calcium salts in the renal parenchyma and is considered the mixed form when it involves the renal cortex and medulla. The main etiological agents of this condition are primary hyperparathyroidism, renal tubular acidosis, medullary sponge kidney, hyperoxaluria and taking certain drugs. These factors can lead to hypercalcemia and/or hype...

A 31-year-old woman with a long history of furosemide abuse presented with abdominal pain. She had been using furosemide (>200 mg per day) for at least the last 15 years. She initially used furosemide to maintain her urinary volume and later for weight loss. Her abdominal pain was caused by paralytic ileus due to hypokalemia (2.1 mEq/L). Although abdominal and pelvic CT revealed no intestinal o...

The clinical data of 18 patients with X linked hypophosphataemia were analysed retrospectively. The height data were expressed as SD scores. There was no difference in the final height of patients treated with vitamin D (or 1,25-dihydroxyvitamin D) and phosphate for at least two years (n = 12) and that of 16 hypophosphataemic family members who had never been treated. The mean final SD score (-...

Figure 1 – Abdominal X-ray of the patient showing clustered calcifications in projection of the kidneys, more evident at the right side (upper arrow identifies one of these clusters). An 8-mm right distal ureteral stone is present (lower arrow). A 46-year-old white woman has been followed in this nephrology clinic since 1995 due to recurrent nephroli-thiasis and medullary nephrocalcinosis resul...

OBJECTIVES To determine prospectively the incidence and cause of nephrocalcinosis in preterm infants. STUDY DESIGN Inborn babies of gestation less than 32 weeks or birth weight less than 1500 g were eligible to be entered into a prospective observational study. Two renal ultrasound scans were performed, the first at 1 month postnatal age and the second at term or discharge. Data were collecte...