background it has been proposed that reactive oxygen species (ros) is involved in the pathogenesis of various diseases. paraoxonase, a high-density lipoprotein associated enzyme, prevents low-density lipoproteins from oxidation. objectives the aim of the present study was to investigate the serum activities of paraoxonase-1 (pon-1), and aryleterase (are) as well as total antioxidant capacity (t...

A 3-year-old girl was presented with periorbital edema, hypertension, proteinuria, and hematuria. She recovered clinically after 9 days with normal urinalysis. During the follow-up, she developed recurrent episodes of nephrotic syndrome. The kidney biopsy revealed mild mesangial proliferation and a low dose of prednisolone could effectively control the disease.Iran J Med Sci 2005; 30(1): 38-40....

BACKGROUND AND OBJECTIVES Steroid-resistant nephrotic syndrome overwhelmingly progresses to ESRD. More than 30 monogenic genes have been identified to cause steroid-resistant nephrotic syndrome. We previously detected causative mutations using targeted panel sequencing in 30% of patients with steroid-resistant nephrotic syndrome. Panel sequencing has a number of limitations when compared with w...

BACKGROUND Nephrotic syndrome is a relatively rare but serious condition in children. Infantile nephrotic syndrome often has a genetic origin; the treatment is then symptomatic, with a poor prognosis, and a rapid evolution to chronic kidney disease. However, non-genetic infantile nephrotic syndrome has been identified. Here we report for the first time in a child a nephrotic syndrome as the sol...

in this case report, we present the first diagnosed case of galloway- mowat syndrome in iran. a 7 month old infant boy with microcephaly that had prominently stunted head growth after birth, gastroesophageal reflux, multiple craniofascial characters, hypothyroidism and nephrotic syndrome diagnosed at 5 months of age associated with rapid decline in renal function and heavy proteinuria in 2 mont...

      Schimke immune-osseous dysplasia (SIOD) is a rare autosomal recessive disorder presented with specific facial features, skeletal dysplasia, steroid resistance nephrotic syndrome (SRNS) and cellular immune insufficiency. This is a SIOD case reported from Iran. He was 5 years old boy when evaluated for proteinuria and short stature. In appearance, we detected hyperpigmented macules, kyphosc...

Background. Nephrotic syndrome is caused by a variety of glomerulopathy. The current study investigated the renal histopathological spectrum of patients with nephrotic syndrome who received a renal biopsy in our department within the last 15 years. Methods. One thousand five hundred and twenty-three consecutive patients ( 14 years old at renal biopsy) with nephrotic syndrome were recruited. Pat...

BACKGROUND AND PURPOSE Thrombosis is one of the main complications of nephrotic syndrome; however, cerebral infarction associated with nephrotic syndrome has been rarely reported. SUMMARY OF REPORT We describe acute cerebral infarction in two young men with nephrotic syndrome. Both had a hypercoagulable state based on hemostatic studies. By retrospectively reviewing the medical records of the...