meningitis is one of the most common infectious cerebral nervous system (cns), defined as an inflammation of the meninges. it is clinically categorized into a chronic and acute based on the acuity of symptoms. vomiting, bulging fontanel and fever are the main symptoms in the patients with meningitis. bacterial meningitis is a severe, potentially life-threatening infection that is associated wit...

Strategies of Schwann cell (SC) transplantation to regenerate the peripheral nerve injury involves many limitations. Stem cells can be used as alternative cell sources for differentiation into SCs. Given the high potential of neural crest-derived stem cells for the generation of multiple cell lineages, in this research, we considered whether olfactory ecto-mesenchymal stem cells (OE-MSCs) derive...

...................................................................................................................... x CHAPTER

Recent studies suggest that endogenous neurotrophins play a central role in the patterning of cortical connections and in cortical synaptic physiology. Do these effects of neurotrophids reflect independent cellular events, or are they manifestations of a single cellular mechanism central to developmental plasticity?

Recent observations suggest that neurotrophins are involved in activity-dependent plasticity of the developing cerebral cortex. What molecular mechanisms underlie activity-dependent competition between axons for trophic factors?

objective: to determine the effects of local administration of platelet rich plasma (prp) on peripheral nerve regeneration in rat sciatic nerve transection model. methods: forty-five male white wistar rats were randomized into three experimental groups (n = 15): normal control group (nc), silicon group (sil), prp treated group (sil/prp). in nc group left sciatic nerve was exposed through a glut...

A previous study has demonstrated that locally administered growth factors such as epidermal growth factor, basic fibroblast growth factor and hepatocyte growth factor can accelerate healing of experimental gastric ulcers in rats. That study indicates that locally administered growth factors can exert potent biological effects resulting in enhanced gastric ulcers healing. However, the fate of i...