Ganglioneuromas are rare benign tumors of neural crest origin developed along the sympathetic chain. The pelvic retroperitoneum is the rarest location of these tumors. Clinically these tumors are commonly asypmtomatic even if they reach large sizes. Here we report the radiological features of a 16 year old boy with pathologically proven retroperitoneal ganglioneuroma that was detected initially...

lectin binding histochemistry was performed on the developing sympathetic ganglionic cells to investigate the distribution and density of defined carbohydrate terminals on the cell surface glycoproteins during autonomic system morphogenesis. sprague-dauley rat embryos from 9th gestational day to birth were fixed and paraffinized. serial sections of these specimens were incubated with different ...

Despite a well-characterized lack of specificity, pathologists routinely employ S100 in the diagnosis of neural crest-derived tumors. Recent studies have shown that Sox10 is a reliable marker of neural crest differentiation that is consistently expressed in schwannian and melanocytic tumors. We sought to validate these results in a larger series of soft tissue neoplasms of both neural crest and...

Malignant peripheral nerve sheath tumor (MPNST) is a rare nerve sheath tumor derived from Schwann cells or pleuripotent cells of neural crest. Neurogenic tumors make about 10-20% of all mediastinal tumors. Incidence of MPNST is 0.001% in general population and 0.16% in patients with neurofibromatosis I (NF I). We report a case of 60 year female presenting with progressive cough and breathlessne...

Melanotic neuroectodermal tumour of infancy is a rare neoplasm of neural crest origin, predominantly affecting the anterior maxilla of infants. Treatment generally consists of surgical excision. Long-term follow-up is important since recurrence and malignant transformation have been reported. The literature about melanotic neuroectodermal tumour of infancy is reviewed and a case occurring in a ...

Neuroblastoma is a neural crest-derived embryonal malignancy, which accounts for 13% of all pediatric cancer mortality, primarily due to tumor recurrence. Therapy-resistant cancer stem cells are implicated in tumor relapse, but definitive phenotypic evidence of the existence of these cells has been lacking. In this study, we define a highly tumorigenic subpopulation in neuroblastoma with stem c...

Neuroblastoma is a neural crest-derived embryonal malignancy, which accounts for 13% of all pediatric cancer mortality, primarily due to tumor recurrence. Therapy-resistant cancer stemcells are implicated in tumor relapse, but definitive phenotypic evidence of the existence of these cells has been lacking. In this study, we define a highly tumorigenic subpopulation in neuroblastoma with stem ce...

Granular cell tumors are rare tumors of Schwann cell origin that arise from tissues of neural crest and mesenchymal origin. We report the clinical, radiographic, and pathological features of a pleural-based granular cell tumor in a 60-year-old African American man.

The author reviewed present status and progress of endocrine nuclear medicine including thyroid, parathyroid, adrenocortical, adrenomedullary and somatostatin receptor imaging and also radionuclide therapy of Basedow's disease, metastatic foci of post-operative thyroid cancer and malignant neural crest tumor. Relatively new imaging agents include 99mTc-MIBI and 99mTc-tetrofosmin for parathyroid...

Pheochromocytomas are the tumor of neural crest cells of adrenal gland secretes Catecholamines (norepinephrine being greater than epinephrine). It causes hypertension in 0.1% of cases.1 80-90 % are solitary tumors localized to single adrenal gland usually right side while 10% are bilateral. They may originate any where in neural crest side from neck to inguinal ligament e.g. right atrium, splee...