Previous studies have demonstrated that the neural tube/notochord complex is required for skeletal muscle development within somites. In order to explore the localization of myogenic inducing signals within the neural tube, dorsal or ventral neural tube halves were cultured in contact with single somites or pieces of segmental plate mesoderm. Somites and segmental plates cultured with the dorsa...

introduction: during early neural tube formation, the notochord is essential for the induction of ectoderm and for the subsequent differentiation of the neuroepithelium forming diverse cell types in the neural tube. due to the key role of the glycoconjugates in many developmental events, the early distribution of these molecules in early notochordal interaction with adjacent tissues were studie...

neural tube defects (ntds) are complex problem of central nervous system including brain and spinal cord. anencephaly and myelomeningocele are the two most common forms of ntds. epidemiological studies reveal that genetic and environmental factors are responsible for the development of ntds. during embryogenesis large numbers of extrinsic and intrinsic factors are responsible for the closer of ...

OBJECTIVE To determine an optimal population red blood cell (RBC) folate concentration for the prevention of neural tube birth defects. DESIGN Bayesian model. SETTING Data from two population based studies in China. PARTICIPANTS 247,831 participants in a prospective community intervention project in China (1993-95) to prevent neural tube defects with 400 μg/day folic acid supplementation ...

Embryonic blood vessels form in a reproducible pattern that interfaces with other embryonic structures and tissues, but the sources and identities of signals that pattern vessels are not well characterized. We hypothesized that the neural tube provides vascular patterning signal(s) that direct formation of the perineural vascular plexus (PNVP) that encompasses the neural tube at mid-gestation. ...

OBJECTIVE The purpose of this study was to identify the relationship of neurotoxic inorganic elements in the hair of patients with the diagnosis of Neural Tube Defects. Our initial hypothesis was that neurotoxic inorganic elements were associated with Neural Tube Defects. METHODS Twenty-three samples of hair from newborns were obtained from the General Hospital, "Aurelio Valdivieso" in the ci...