Small round cell tumors of childhood can be histologically ambiguous, can require tumor markers for an accurate diagnosis, and include neuroblastoma, peripheral primitive neuroectodermal tumor (pPNET), Ewing's sarcoma (ES), lymphoma, and rhabdomyosarcoma. Because the cell type of origin for ES remains controversial, characterizing gene expression in ES can provide diagnostic markers and lead to...

Primitive neuroectodermal tumors (PNETs) are small round cell malignant tumors classified as part of the Ewing’s sarcoma family of neoplasms, which represents approximately 1% of all sarcomas1. Predominantly occurring in soft tissues along the extremities, they have also been reported in a variety of organs such as kidney, urinary bladder, testis, ovary, uterus, heart and lung2, 3. Pancreatic P...

BACKGROUND Ewing's family of tumors (EFT) comprises a broad spectrum of tumors composed of primitive committed cells with neuroectodermal capacity. The degree of neural differentiation within EFT, as measured with morphological features and expression of neural markers, delimits two members: Ewing's sarcoma (ES) and peripheral primitive neuroectodermal tumor (pPNET). Molecules such as c-kit and...

Olfactory neuroblastoma (ONB) is a malignant tumor of the nasal mucosa whose histogenesis is unclear. A relationship to neuroblastoma (NB), a pediatric tumor of the sympathetic nervous system, is based on morphologic similarities and the expression of similar neural antigens. However, the clinical presentation of ONB differs from that of NB, and MYCN amplification characteristic of NB is not ob...

Pediatric primary "small round blue cell" tumors in the CNS represent several entities, some more common than others. Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) is rare and must be distinguished from other tumors such as medulloblastoma [1, 2], atypical rhabdoid/teratoid tumor, ependymomal tumors, metastatic sarcomas, hematologic malignancies, and other mimics. Although...

primitive  neuroectodermal  tumor  (pnet)  of  kidney  is  an  extremely  rare  renal  neoplasm  with only about fifty reported cases in literature.  presumably,of neural crest origin, these tumors behave  aggressively  and  carry  a  poor prognosis.  we  report  a  case  of  22-year  old  female  patient complaining of left loin pain with recurrent hematuria for last 3 months. on clinical exam...

conclusions pnet/ews should be included in the differential diagnosis of renal tumors in symptomatic young adults. patients with localised pnet/ews treated with a combination of surgery and chemotherapy have an excellent chance of long-term survival, as in the case we have presented. introduction primitive neuroectodermal tumor (pnet)/ewing’s sarcoma (ews) belongs to a family of neoplasms that ...

primitive neuroectodermal tumor (penets) is an uncommon malignancy of bone and soft tissue witch rarely occurs in the kidney. in more than 90% of the cases, the tumor cells relieves a balanced translocation (11; 22) (q24; q12). immunohistochemical staining may be required for diagnosis of penet. the cells of tumor express cd99, vimentin, nse, fl1 but do not express ck, lca, myogenin, and wt1. w...

Primary intraspinal primitive neuroectodermal tumor (PNET) is a type of round cell malignant which reported only above 100 in literature. We report case Dorsal Spine Primitive Neuroectodermal Tumor (P.N.E.T) Presenting with Features Pott’s Spine, & discuss its pathological features, radiology, and treatment options.