Until recently, the central nervous system (CNS) has been thought to be an immune privileged organ. However, it is now understood that neuroinflammation is linked with the development of several CNS diseases including late-onset Alzheimer's disease (LOAD). The development of inflammation is a complex process involving a wide array of molecular interactions which in the CNS remains to be further...

It is vulnerable for aged subjects to postoperative cognitive dysfunction and many proof suggested exaggerated neuroinflammation after surgery is the vital cause, but the mechanism needs to be disclosed. Autophagy can inhibit inflammation and itself has protective effect on nervous system. The study aimed to explore whether autophagy itself and/or its anti-neuroinflammation action in hippocampu...

after alzheimer disease, parkinson disease (pd) is considered the most common neurodegenerative disease. its prevalence is the same in all area but it is common in males than females. from every 100 persons who are above 60 years old, one of them has pd. also 5-10% of patients are less than 40 years old. this progressive neuroinflammation disease isn’t fatal. in 60% of cases is with depression....

neuroinflammation has a significant role in induce of multiple sclerosis (ms) many approaches have been used to treat ms, but none of these methods have not been able to fully improve. one of the methods can suppress inflammation and regenerate the nervous system is the use of cell therapy. using cell therapy in pre-clinic phase can be realized, it's mechanism and potency to suppress neuro...

Neuroinflammation is a complex inflammatory process in the central nervous system, which is sought to play an important defensive role against various pathogens, toxins or factors that induce neurodegeneration. The onset of neurodegenerative diseases and various microbial infections are counted as stimuli that can challenge the host immune system and trigger the development of neuroinflammation...

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and many survivors experience a wide range of neurological impairments after TBI. Following the initial mechanical injury at the moment of a TBI event, various cellular and molecular processes are activated as the secondary injury. Neuroinflammation is an important mechanism involved in the secondary injury of TBI...

Traumatic brain injury (TBI) is a common cause of death which affects millions of people around the world. TBI is also associated with various neurological impairments. After the primary mechanical injury at the moment of a TBI event, several cellular and molecular processes are activated within the brain tissue as the secondary injury. An important mechanism involved in the secondary injury of...

Depression alone is a severe and acute disease, but its close relationship with neuroinflammation and neurodegenerative diseases has emphasized its importance. In fact, the linking bridges between depression and these diseases are cytokines, especially pro-inflammatory cytokines which have fundamental roles in organizing different parts of central nervous system and emotions. Studying the relat...

Abstract Forkhead transcription factor (FoxO) plays key roles in the induction of various downstream genes involved inhibition cellular metabolism, cell death, cycle, and oxidative stress responses. FoxO6 is expressed liver, skeletal muscle, hippocampus brain. also has been proposed to play a role promotion insulin resistance, inflammation. In this study, we tried determine neuroinflammation in...