Neuromedin U (NMU) was originally identified as an anorexigenic peptide that modulates appetite as well as energy homeostasis through the brain-gut axis. Although growing evidence has linked NMU activity with the development of female reproductive organs, no direct expression of and function for NMU in these organs has been pinpointed. Using a superovulated rat model, we found that NMU is direc...

Christoph Melcher, Rüdiger Bader, Steffen Walther, Oleg Simakov, Michael J. Pankratz We recently provided a molecular, neuroanatomical, and behavioral analyses of neurons expressing the neuropeptide gene hugin in Drosophila [1]. hugin-expressing neurons appear to comprise a neural circuitry in the brain that modulates feeding behavior in response to gustatory and nutrient signals. One of the qu...

objective(s): neuroprotective effects of female gonadal steroids are mediated through several pathways involving multiple peptides and receptors after traumatic brain injury (tbi). two of these peptides are including the regulatory peptides neuromedin u (nmu) and neuromedin s (nms), and their common receptor neuromedin u2 receptor (nmur2). this study investigates the effects of physiological do...

Neuromedin S (NMS), a 36 amino acid peptide structurally related to neuromedin U, identified in rat brain as ligand for the G protein-coupled receptor FM4/TGR-1, also termed neuromedin U receptor type-2 (NMU2R). Its central expression is restricted to the suprachiasmatic nucleus, and involved in the regulation of dark light rhythms and suppression of food intake. Stimulatory role of NMS on hypo...