background: bone marrow stromal stem cells (bmsc) are appropriate source of multipotent stem cells that are ideally suited for use in various cell-based therapies. it can be differentiated into neuronal-like cells under appropriate conditions. this study examined the effectiveness of co-stimulation of creatine and retinoic acid in increasing the differentiation of bmsc into gabaergic neuron-lik...

background: adult stem cells (asc) are undifferentiated cells found throughout the body. these cells are promising tools for cell replacement therapy in neurodegenerative disease. adipose tissue is the most abundant and accessible source of asc. this study was conducted to evaluate effect of selegiline on differentiation of adipose-derived stem cells (adsc) into functional neuron-like cells (nl...

Background: Bone marrow stromal stem cells (BMSC) are appropriate source of multipotent stem cells that are ideally suited for use in various cell-based therapies. It can be differentiated into neuronal-like cells under appropriate conditions. This study examined the effectiveness of co-stimulation of creatine and retinoic acid in increasing the differentiation of BMSC into GABAergic neuron-lik...

introduction: embryonic stem (es) cells are pluripotent cells derived from inner cell mass of blastocyst. these cells can product any cell by spontaneous or directed differentiation. this study was started to produce neuron cells by directed differentiation of new murine es cell line in vitro. materials and methods: murine es cells (royan b1 derived from c57bl/6 strain) were used for in vitro n...

objective: cd133+ umbilical cord blood cells were identified as a hematopoietic stem cell which has the capacity for extensive self-renewal and differentiation. the aim of this study was to identify the effect of staurosporine (sts), a wellknown protein kinase inhibitor on differentiation of cd133+ cells into neural cells. materials and methods: cd133+ cells were enriched by immunomagnetic bead...

Background: Adult stem cells (ASC) are undifferentiated cells found throughout the body. These cells are promising tools for cell replacement therapy in neurodegenerative disease. Adipose tissue is the most abundant and accessible source of ASC. This study was conducted to evaluate effect of selegiline on differentiation of adipose-derived stem cells (ADSC) into functional neuron-like cells (NL...

Introduction: The aim of this study was evaluate the ability of notochord to induce neural induction and/or differentiation of mouse embryonic stem cell to neuron and motor neuron, respectively. Methods: In order to produce embryoid bodies, ES cells line Royan B1 were grown in suspension in the absence of LIF for 4 days. EBs were divided into 4 groups. EBs in group 1 & 2 were further cultur...

Objective(s): Nowadays much effort is being invested in order to diagnose the mechanisms involved in neural differentiation. By clarifying this, making desired neural cells in vitro and applying them into diverse neurological disorders suffered from neural cell malfunctions could be a feasible choice. Thus, the present study assessed the capability of fetal brain extract (FBE) to induce rat bon...

cell replacement therapy has provided the basis for future clinical applications to treat central nervous system injury, a common result of car accidents. induced functional motoneurons are an option for replacing the lost motoneurons. adipose derived stem cells (adscs) are an appropriate source of cells for autologous cell therapy with the ability of neural differentiation. in this study, adsc...