Neuropathologically speaking, syphilis is a sexually transmitted acute or chronic infection caused by the spirochete Treponema pallidum. Disease manifestations are diverse, occurring in stages: primary, secondary, latent and tertiary (late). Neurosyphilis is regarded as a manifestation of tertiary syphilis, but the spirochete may invade the central nervous system early in the course of infectio...

BACKGROUND To describe 4 patients with bilateral tonic pupils in neurosyphilis. CASES Four young men had pupillary abnormalities, which involved irregular shapes, large sizes, tonic reactions, and vermiform movements of both pupils with light-near dissociation. Cholinergic supersensitivity defined bilateral tonic pupils. OBSERVATIONS Neurosyphilis was diagnosed in these patients on the basi...

The ratio of patients with RPR constant positive more than 2 years despite receiving standard syphilis treatment has been reported to be 11.54%~31.3%. The current interpretations on this phenomenon are cellular immune function restrained and the existence of neurosyphilis or asymptomatic neurosyphilis. We conducted this study to detect the treponemal antibody in cerebrospinal fluid (CSF) and ly...

Neurosyphilis is a chronic infectious disease with involvement of central nervous system infection by Treponema pallidum. This study was to investigate the contents of B lymphocyte chemokine 1 (BLC-1/chemokine [C-X-C motif] ligand 13), Th1 cytokines (Interleukin [IL]-2, IL-12, and Interferon [IFN]-γ), and Th2 cytokines (IL-6 and IL-10) in serum and cerebrospinal fluid (CSF) of HIV-negative pati...

Neurosyphilis can cause both symptomatic and asymptomatic meningitis. However the epidemiology of modern neurosyphilis is not well defined because of the paucity of population-based data. The majority of neurosyphilis cases have been reported in HIV-infected patients. Here we present a case of early neurosyphilis/symptomatic syphilitic meningitis in a non-HIV patient who presented with rash but...

Syphilis is a sexually transmitted disease caused by a spirochete, Treponema pallidum (T. pallidum). Involvement of the central nervous system (CNS) occurs in 5-30% of the patients and the CNS may be affected at any stage of the disease (1). It is difficult to differentiate neurosyphilis from other cerebral infectious and inflammatory diseases, because of its various times of onset and diverse ...

A delusional, agitated middle-aged man presented to hospital with a tenacious psychotic episode. Upon appropriate therapy for neurosyphilis, dramatic resolution of this brief episode ensued, prompting a literature review of psychosis associated with neurosyphilis.

The first choice treatment for late syphilis is penicillin. Other than doxycycline, which penetrates the CNS, there are few alternatives for the treatment of neurosyphilis. We report a case of successful treatment of symptomatic neurosyphilis with parenteral ceftriaxone.

Neurosyphilis is a recognized cause of epileptic seizures and cognitive impairment, but is not usually associated with the finding of generalized periodic activity in the EEG. We report two similar cases characterized by progressive cognitive impairment followed by partial complex seizures, in whom the EEG showed generalized periodic activity. Both cerebrospinal fluid and the response to penici...

Treponema pallidum subspecies causes syphilis, a sexually transmitted disease that infects more than 2.1 million pregnant women every year. Due to its maximum death rates and augmented risk of human immunodeficiency virus (HIV) infection, the is still matter debate in many low- high-income countries. The infection has three stages lead several complications if left untreated can tertiary brain,...