نتایج جستجو برای: newborn immunity
تعداد نتایج: 136335 فیلتر نتایج به سال:
objective: infectious microorganisms are major sources of illness and death worldwide, and the leading cause of death in neonates. effective vaccination of this age group is of particular importance. the lack of a response and greater susceptibility to tolerance are two major features that limit the effectiveness of vaccines in neonates. in this study we compare the cellular immune response gen...
The newborn and infant periods of early life are associated with heightened vulnerability to infection. Limited antigen exposure and distinct adaptive immune function compared to the adult places a greater burden on innate immunity for host defense to microbial challenge during this time. Trained immunity describes the phenomenon of augmented innate immune function following a stimulus that is ...
Immunization is key to preventing infectious diseases, a leading cause of death early in life. However, due to age-specific immunity, vaccines often demonstrate reduced efficacy in newborns and young infants as compared to adults. Here, we combined in vitro and in vivo approaches to identify adjuvant candidates for early life immunization. We employed newborn and adult bone marrow-derived dendr...
BACKGROUND In adult rats, initial exposure to antigens by a mucosal route triggers tolerance such that any subsequent re-exposure, even by a systemic route, results in suppression of immunity. The newborn's gut is semi-permeable for a finite period to allow maternal antibodies to enter the newborn's circulation. We propose that antigens introduced in extreme early life can readily traverse the ...
Tests for transplantation immunity and for the occurrence of virus-neutralizing serum antibodies were performed on mice, inoculated when newborn with the Schmidt-Ruppin strain of Rous sarcoma virus (RSV-SR). Mice developing no palpable primary sarcomas showed a clear-cut resistance against the isografting of established specifically antigenic Rous tumors. Transplantation tests performed on prim...
Recent studies have radically changed our views of the development of acquired immunity during gestation and perinatal life. It is now apparent that there are considerable differences in the way the immune response matures in different species (Sterzl and Silverstein, 1967; Adinolfi and Wood, 1969; Solomon, 1971). In mice and rats immune reactions are relatively immature even in the newborn. In...
Recent studies have radically changed our views of the development of acquired immunity during gestation and perinatal life. It is now apparent that there are considerable differences in the way the immune response matures in different species (Sterzl and Silverstein, 1967; Adinolfi and Wood, 1969; Solomon, 1971). In mice and rats immune reactions are relatively immature even in the newborn. In...
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