nf-κb pathway is a link between inflammation and cancer and is involved in cellular responses to different stimuli. gastrointestinal lumen is exposed to many inflammatory agents such as foods, free radicals and bacterial or viral antigens. the aim of the present study was to evaluate the possible role of nf-κb1in gastric adenocarcinoma. to detect the relative level of nf-κb1transcript, total rn...

Nuclear factor-κB (NF-κB) is important in inflammatory skin diseases, including contact dermatitis (Th1 inflammation), atopic (Th2 and psoriasis (Th17 inflammation). In fact, molecularly targeted drugs against tumor necrosis factor (TNF), which both upstream downstream of NF-κB have been demonstrated to be effective diseases such as psoriasis. The linear ubiquitination by ubiquitin chain assemb...

Objectives. The effects of Kluyveromyces marxianus on high-fat diet- (HFD-) induced kidney injury (KI) were explored. Methods. HFD-induced KI model was established using male C57BL/6 mice and treated with K. JLU-1016 acid-resistant (AR) strain JLU-1016A. Glucose tolerance evaluated via an oral glucose test (OGTT). measured Hematoxylin Eosin (H&E) staining terminal deoxynucleotidyl transfera...

Background and Aim. Daphnetin, an active monomer ingredient extracted from D. marginata, is proved to have anti-inflammatory antioxidant effect. The aim of this study explore the effect possible mechanism daphnetin on acute lung injury (ALI) associated with pancreatitis (AP) in mice. Methods. A total 36 mice were randomly assigned into three groups: control group, AP group. mouse model was indu...

NF-κB signaling is essential to an effective innate and adaptive immune response. Many immune-specific functional developmental outcomes depend in large on NF-κB. The formidable task of sorting out the mechanisms behind regulation outcome remains important area immunology research. Here we briefly discuss role regulating cell fate decisions at various times path B development, activation, gener...

Background: The death of neurons and cerebral edema are the main consequences of stroke. However, inflammatory processes play a key role in aggravating cerebral damage following stroke. The aim of this study was to investigate the effects of Viola odorant extract (VOE) on infarct volume (IV), neurologic deficits (ND), and expression of NF-κB and VCAM-1 in the MCAO model. Method: The animals we...

NF-κB pathway is a link between inflammation and cancer and is involved in cellular responses to different stimuli. Gastrointestinal lumen is exposed to many inflammatory agents such as foods, free radicals and bacterial or viral antigens. The aim of the present study was to evaluate the possible role of NF-κB1in gastric adenocarcinoma. To detect the relative level of NF-κB1transcript, total RN...

our prior study found  that transforming growth factor  beta-induced (tgfbi) is  an important negative regulator in tlr-induced inflammation. however, whether tgfbi may affect inflammation during lipopolysaccharide (lps)-induced endotoxin tolerance (et) is still unclear.this study aimed to investigate whether tgfbi was involved in the mechanisms of et in human through dampening nuclear factor-k...

objective: recent studies suggest that intermittent and prolonged normobaric hyperoxia (ho) results in ischemic tolerance to preventing ischemia brain injury. in this research attempts were made to see the changes in excitatory amio-acid transporter 3 (eaat3), tnf-α levels, and nf-κb activity following prolonged and intermittent nbho preconditioning. materials and methods: rats were divided i...

The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-κB plays in key physiological processes makes it an important factor in determining hea...