The relative toxicity and carcinogenicity of nickel sulfate hexahydrate (NiSO4.6H2O), nickel subsulfide (Ni3S2), and nickel oxide (NiO) were studied in F344/N rats and B6C3F1 mice after inhalation exposure for 6 h/day, 5 days/week for 2 years. Nickel subsulfide (0.15 and 1 mg/m3) and nickel oxide (1.25 and 2.5 mg/m3) caused an exposure-related increased incidence of alveolar/bronchiolar neoplas...

toxicity has occurred in workers exposed to nickel dust or nickel carbonyl formed in refining. increased risk of nasal and lung cancers was linked to occupational nickel exposure before current workplace safety standards were set. activated carbon with nano holes used for removing contaminants in environment. the purpose of this work is preparation a new nano-absorber, gz-baki-tac-ni-88, for th...

Complex engineered nanomaterials (CENs) are a rapidly developing class of structurally and compositionally complex materials that are expected to dominate the next generation of functional nanomaterials. The development of methods enabling rapid assessment of the toxicity risk associated with this type of nanomaterial is therefore critically important. We evaluated the toxicity of three differe...

Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity. To identify genes that modulate zinc tolerance, we performed a forward genetic screen for Caenorhabditis elegans mutants that were resistant to zinc toxicity. Here we demonstrate that mutations of the...

Although there have been numerous studies examining the toxicity and carcinogenicity of nickel compounds in humans and animals, its molecular mechanisms of action are not fully elucidated. In our research, NIH/3T3 cells were exposed to nickel-refining fumes at the concentrations of 0, 6.25, 12.50, 25, 50 and 100 μg/mL for 24 h. Cell viability, cell apoptosis, reactive oxygen species (ROS) level...

Toxicity has occurred in workers exposed to nickel dust or nickel carbonyl formed in refining. Increased risk of nasal and lung cancers was linked to occupational nickel exposure before current workplace safety standards were set. Activated carbon with nano holes used for removing contaminants in environment. The purpose of this work is preparation a new nano-absorber, GZ-BAKI-TAC-Ni-88, for th...

The many chemical forms of nickel differ in physicochemical properties and biological effects. Health assessments for each main category of nickel species are needed. The carcinogenicity assessment of water-soluble nickel compounds has proven particularly difficult. Epidemiologic evidence indicates an association between inhalation exposures to nickel refinery dust containing soluble nickel com...

To assess nickel-induced toxicity in plants, Zea mays seeds were germinated and cultured on nutrient solution with nickel concentrations of 50-200 μM for a period of two weeks. Observed biological makers included biomass, soluble and total protein contents, and the activities of guaiacol peroxidase (GPX), ascorbate peroxidase (APX), catalase (CAT), and phenylalanine ammonia-lyase (PAL) in the l...

Toxicity has occurred in workers exposed to nickel dust or nickel carbonyl formed in refining. Increased risk of nasal and lung cancers was linked to occupational nickel exposure before current workplace safety standards were set. Activated carbon with nano holes used for removing contaminants in environment. The purpose of this work is preparation a new nano-absorber, GZ-BAKI-TAC-Ni-88, for th...

Nicotianamine, a plant-derived chelator of metals, is produced by the trimerization of S-adenosylmethionine catalyzed by nicotianamine synthase. We established transgenic Arabidopsis and tobacco plants that constitutively overexpress the barley nicotianamine synthase gene. Nicotianamine synthase overexpression resulted in increased biosynthesis of nicotianamine in transgenic plants, which confe...