Objective: This study aims to explore the incidence and risk factors of nosocomial infections (NIs) in the intensive care unit (ICU) in China. Methods: Between January 2011 and December 2013, a total of 1718 patients with a mean age of 59.02 ± 20.71 years in ICU were included. Clinical data of these patients, including gender, age, length of stay, the overall rate of patients with NIs, the dist...

The sodium/iodide symporter (NIS) is a membrane transport glycoprotein normally expressed in the thyroid gland and lactating mammary gland. NIS is a target for radioiodide imaging and therapeutic ablation of thyroid carcinomas and has the potential for similar use in breast cancer treatment. To facilitate NIS-mediated radionuclide therapy, it is necessary to identify signaling pathways that lea...

In recent years, several marine non-indigenous species (NIS) lists have been produced for many European countries but little is known about the diversity and distribution of fouling NIS in Portugal (mainland and islands). We conducted a six-year survey of a marina located on the south coast of Madeira island, Portugal to assess NIS diversity on the island, constituting the first NIS inventory f...

The selective increase of Na(+)/I(-) symporter (NIS)-mediated active iodide uptake in thyroid cells allows the use of radioiodine I(131) for diagnosis and targeted treatment of thyroid cancers. However, NIS-mediated radioiodine accumulation is often reduced in thyroid cancers due to decreased NIS expression/function. As PI3K signaling is overactivated in many thyroid tumors, we investigated the...

Absorption of dietary iodide, presumably in the small intestine, is the first step in iodide (I(-)) utilization. From the bloodstream, I(-) is actively taken up via the Na(+)/I(-) symporter (NIS) in the thyroid for thyroid hormone biosynthesis and in such other tissues as lactating breast, which supplies I(-) to the newborn in the milk. The molecular basis for intestinal I(-) absorption is unkn...

AIMS To investigate the expression of sodium/iodide symporter (NIS) and thyroid stimulating hormone receptor (TSHR) in human thyroid cancer. PATIENTS AND METHODS NIS and TSHR mRNA levels quantified by real-time PCR as well as NIS and TSHR proteins evaluated by immunohistochemistry were examined in surgical specimens including 38 benign nodules, 32 thyroid carcinomas and 36 normal thyroid samp...

Iodide is concentrated to a much lesser extent by papillary thyroid carcinoma as compared with the normal gland. The Na+/I- symporter (NIS) is primarily responsible for the uptake of iodide into thyroid cells. Our objective was to compare NIS mRNA and protein expression in papillary carcinomas with those in specimens with normal thyroid. Northern blot analysis revealed a 2.8-fold increase in th...

UNLABELLED Increased expression of the sodium iodide symporter (NIS) is required for effective radioiodine treatment and reporter gene imaging of breast cancer. We investigated the effect of retinoic acid on adenovirus-mediated expression of the human NIS gene in the MCF-7 breast cancer cell line. METHODS The MCF-7 cell line was infected with recombinant adenovirus carrying the human NIS gene...

Marine biological invasions threaten biodiversity worldwide. Here we explore how Marine Protected areas, by reducing human use of the coast, confer resilience against the introduction of non-indigenous species (NIS), using two very different Pacific islands as case studies for developing and testing mathematical models. We quantified NIS vectors and promoters on Vancouver (Canada) and Moorea (F...

Synopsis. Non-indigenous species (NIS) are increasingly conspicuous in marine and estuarine habitats throughout the world, as the number, variety, and effects of these species continue to accrue. Most of these NIS invasions result from anthropogenic dispersal. Although the relative importance of different dispersal mechanisms varies both spatially and temporally, the global movement of ballast ...