BACKGROUND The efficacy of antimicrobial urinary catheters in hospitalized patients is poorly defined. PURPOSE To assess currently marketed antimicrobial urinary catheters for preventing catheter-associated urinary tract infection (UTI). DATA SOURCES Electronic databases, conference proceedings, bibliographies, trialists, and catheter manufacturers (search dates, 1966 to June 2005). STUDY...

Nitromidazole and nitrofuran derivatives comprise a large family of compounds, some of which have been shown to be hypoxic cell specific radiosensitizers in vivo and in vitro. The effects of metronidazole (2-methyl-5-nitroimidazole-1-ethanol) and nitrofurazone (5-nitro-2-furaldehyde semicarbazone) were studied on cell viability in vitro in the presence of air or nitrogen in the absence of radia...

1. The mechanism of release of a pyrogen from leucocytes has been studied in cells obtained from sterile rabbit peritoneal exudates and from rabbit blood. Attempts were made to induce human leucocytes-from blood-to release a pyrogen. 2. Rabbit leucocytes, kept below 4 degrees C., were not pyrogenic and did not release any pyrogen when disintegrated. Incubating such cells, in various media, at 3...

BACKGROUND Therapeutic effects of various treatment options in burn wound healing have been one of the most controversial issues in wound care. Aloe Vera is an herbal medicine, which has wound healing effects on chronic wound. The present study was carried out to examine and compare the effect of Aloe Vera gel and nitrofurazone 2% on epithelialization and granulation tissue formation with respe...

Nitrofurazone is one of the antibacterial nitrofuran agents used topically for skin infections. The drug is effective on the majority of infectious microorganisms. Because of the importance of this drug in clinic, in this study various methods of synthesis of nitrofurazone were examined and the most appropriate method, applicable to pharmaceutical industry was chosen and optimized from the poin...

The addition of a hydroxymethyl group to the antimicrobial drug nitrofurazone generated hydroxymethylnitrofurazone (NFOH), which had reduced toxicity when its activity against Trypanosoma cruzi was tested in a murine model of Chagas' disease. Four groups of 12 Swiss female mice each received 150 mg of body weight/kg/day of NFOH, 150 mg/kg/day of nitrofurazone (parental compound), 60 mg/kg/day o...

Mast cells have been shown to participate in the wound healing process. We investigated the effects of low-level laser therapy (LLLT) on mast cell number in the inflammation, proliferation, and remodeling phases of the wound healing process of experimental burns. Sixty rats subjected to third-degree burns were divided into four groups: two laser-treated, one control, and one nitrofurazone-treat...