objective(s):recent evidence have proposed that tretinoin produced in the gut preferentially promote differentiation of foxp3+treg cells but inhibits th17 lymphocytes, and this may be the main immunomdulatory mechanism of tretinoin  in vivo. this study was done to investigate the effects of tretinoin in outbred white mice after challenge with sheep red blood cells (srbc). materials and methods:...

conclusions tachyzoite of toxoplasma and dna of this parasite were observed in sub mucosa and muscles of the uterus and in the villis of placenta, but not in histological sections of the fetus. therefore, histological and molecular results were consistent. background toxoplasma gondii is an important zoonotic pathogen. vertical transmission of the parasite occurs when females were infected prim...

abstract background: research studies on reproductive mechanism of laboratory animals are essential for further advancement of assisted reproductive techniques (art). one of these studies includes the assessment of in-vitro development of pre-implantation embryos. the objective was to compare the cleavage rates and morphology of in-vivo formed 2 to 8 cell embryos and blastocysts with in-vitro c...

In humans, the ingestion of the combination of two or more serotonin (5-HT)-enhancing drugs but also of a single drug in overdose can induce serious adverse effects, which are characteristics of the serotonin syndrome (SS). In mice, acute administration of direct and indirect 5-HT agonists also leads to behavioral and autonomic responses, but in literature different responses are thought to be ...

Apoptosis has a critical role in the pathogenesis of bleomycin induced-pulmonary fibrosis. The severity of fibrosis varies among different strains of mice. Recent studies have indicated that expression of apoptotic regulatory genes may be specific in different cell types in various strains. In this study, bleomycin-induced pulmonary apoptosis in NMRI (Naval Medical Research Institute, USA) albi...