Epithelia are bound by both basal and apical extracellular matrices (ECM). Although the composition and function of the former have been intensively investigated, less is known about the latter. The embryonic sheath, the ECM apical to the Caenorhabditis elegans embryonic epidermis, has been suggested to promote elongation of the embryo. In an RNAi screen for the components of the sheath, we ide...

Professor Lars Noah deserves much credit for exposing some of the myriad ways in which the Food and Drug Administration (FDA) has consistently sought to expand its authority through questionable, and perhaps in some cases abusive, legal practices.1 As Professor Noah observes, there are signs that the federal courts’ century-long honeymoon with the FDA may be ending2—and perhaps the FDA never de...

Groundwater is a major source of water in the western US. However, there are limited recharge estimates available in this region due to the complexity of recharge processes and the challenge of direct observations. Land surface Models (LSMs) could be a valuable tool for estimating current recharge and projecting changes due to future climate change. In this study, simulations of three LSMs (Noa...

Modulo formatting, this document constitutes a portion of my application for tenure (“section 5”). It details my research, teaching, and service efforts and goals. It is not exhaustive, and it reflects my view of my activities in late May 2013. 1 Research My research goal is to automate inference from natural language text, including: • algorithms that interpret text into abstract linguistic st...

The NOAH/DIAMOD program suite was used to automatically assign an experimental 2D NOESY spectrum of the 46 residue protein crambin(S22/I25), using feedback filtering and self-correcting distance geometry (SECODG). Automatically picked NOESY cross peaks were combined with 157 manually assigned peaks to start NOAH/DIAMOD calculations. At each cycle, DIAMOD was used to calculate an ensemble of 40 ...

[1] The augmented Noah land surface model described in the first part of the two‐part series was evaluated here over global river basins. Across various climate zones, global‐scale tests can reveal a model’s weaknesses and strengths that a local‐scale testing cannot. In addition, global‐scale tests are more challenging than local‐ and catchment‐scale tests. Given constant model parameters (e. g...