There are three major types of sleep-disordered breathing (SDB) with respect to prevalence and health consequences, i.e. obstructive sleep apnoea syndrome (OSAS), Cheyne-Stokes respiration and central sleep apnoea (CSR-CSA) in chronic heart failure, and obesity hypoventilation syndrome (OHS). In all three conditions, hypoxia appears to affect body functioning in different ways. Most of the mole...

Erectile dysfunction (ED) is common among men with obstructive sleep apnea (OSA) with reports of prevalence varying from 30 – 50 percent. The mechanism is unknown. Since chronic hypoxia is known to cause peripheral neuropathies, it is logical to question whether ED in OSA might reflect peripheral neuropathy resulting from the intermittent nocturnal hypoxia concomitant with OSA. Two recent studi...

BACKGROUND Sleep apnea is an important comorbidity in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). Although the increased prevalence of sleep apnea in patients with ESRD is well established, few studies have investigated the prevalence of sleep apnea in patients with nondialysis-dependent kidney disease, and no single study, to our knowledge, has examined the f...

BACKGROUND The association of obstructive sleep apnea (OSA) with glucose intolerance and the beneficial effect of lifestyle intervention have been poorly investigated in women particularly before menopausal status. The study explored 1) whether OSA is associated with impaired glucose homeostasis in obese non diabetic premenopausal and menopausal women and 2) the effects of a 3- month lifestyle ...

OBJECTIVE The possible effects of blue light during acute hypoxia and the circadian rhythm on several physiological and cognitive parameters were studied. METHODS Fifty-seven volunteers were randomly assigned to 2 groups: nocturnal (2200-0230 hours) or diurnal (0900-1330 hours) and exposed to acute hypoxia (4000 m simulated altitude) in a hypobaric chamber. The participants were illuminated b...

BACKGROUND AND PURPOSE Patients with TIA and minor stroke are at high risk for recurrent stroke. Obstructive sleep apnea (OSA) may increase this risk. The objectives of our study were to determine the prevalence and severity of OSA and its clinical presentation in this population. METHODS Patients who presented with TIA and minor stroke completed a questionnaire and nocturnal cardiopulmonary ...

daily activity cycles, together with changes in activity and ventilation frequency in response to hypoxia (PO2 about 8 kPa), have been measured in unrestrained, unoperated dogfish. Continuous recording of activity over 48 h reveals that dogfish are essentially nocturnal, being three to four times more active at night than during the day. In relatively inactive, diurnal dogfish, rapid reduction ...