Figure 4. From left to right: maps of FA (from DTI), intracellular fraction, CSF fraction and ODI (from NODDI) in the same lesion shown in fig.3 NODDI performs better than DTI in brain tumors with vasogenic edema Matteo Figini, Giuseppe Baselli, Marco Riva, Lorenzo Bello, Hui Zhang, and Alberto Bizzi Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, MI, I...

PURPOSE This study was a systematic evaluation across different and prominent diffusion MRI models to better understand the ways in which scalar metrics are influenced by experimental factors, including experimental design (diffusion-weighted imaging [DWI] sampling) and noise. METHODS Four diffusion MRI models-diffusion tensor imaging (DTI), diffusion kurtosis imaging (DKI), mean apparent pro...

Tracing white matter fiber bundles is an integral part of analyzing brain connectivity. An accurate estimate of the underlying tissue parameters is also paramount in several neuroscience applications. In this work, we propose to use a joint fiber model estimation and tractography algorithm that uses the NODDI (neurite orientation dispersion diffusion imaging) model to estimate fiber orientation...

rats (i, red color), the controlateral part (ii, blue color) and the ipsilateral part (iii, green color). For DIAMOND: λ⁄⁄ ,λ⊥: axial and radial diffusivities, hei: heterogeneity index, Diso: Diffusion isotropic, and fDiso: fraction of Diso. For NODDI: ficvf: intra-cellular volume fraction, fiso: CSF volume fraction and odi: orientation dispersion index. * : statistically significant Characteri...

Tract-based spatial statistics (TBSS) has proven to be a popular technique for performing voxel-wise statistical analysis that aims to improve sensitivity and interpretability of analysis of multi-subject diffusion imaging studies in white matter. With the advent of advanced diffusion MRI models - e.g., the neurite orientation dispersion density imaging (NODDI), it is of interest to analyze mic...

Preterm birth is a major public health concern, with the severity and occurrence of adverse outcome increasing with earlier delivery. Being born preterm disrupts a time of rapid brain development: in addition to volumetric growth, the cortex folds, myelination is occurring and there are changes on the cellular level. These neurological events have been imaged non-invasively using diffusion-weig...

Mechanisms underlying phenotypic heterogeneity in young onset Alzheimer disease (YOAD) are poorly understood. We used diffusion tensor imaging and neurite orientation dispersion and density imaging (NODDI) with tract-based spatial statistics to investigate apolipoprotein (APOE) ε4 modulation of white-matter damage in 37 patients with YOAD (22, 59% APOE ε4 positive) and 23 age-matched controls. ...

Diffusion tensor imaging (DTI) studies have provided much evidence of white and subcortical gray matter changes during late childhood and early adolescence that suggest increasing myelination, axon density, and/or fiber coherence. Neurite orientation dispersion and density imaging (NODDI) can be used to further characterize development in white and subcortical grey matter regions in the brain b...

Abstract Background Neurite Orientation Dispersion and Density Imaging (NODDI), derived through multi‐shell diffusion MRI, allows for the estimation of markers pertaining to multiple distinct components neural tissue microstructure. Lower neurite density index (NDI), lower orientation dispersion (ODI), higher volume fraction isotropic water (V iso ), have all been significantly associated with ...