O prurigo nodular corresponde a uma doença dermatológica crônica com características clássicas. Sua fisiopatologia ainda não foi totalmente esclarecida pela literatura atual, contudo, está invariavelmente associada alteração de densidade nervosa nervos periféricos e um processo inflamatório crônico. Na abordagem paciente provável diagnóstico dessa patologia, será preciso descartar condições que...

An 80-year-old woman diagnosed with rheumatoid arthritis 22 years ago and with no other relevant medical or allergic conditions had been treated with methotrexate and prednisone for 2 years with good control of disease activity. In January 2007, methotrexate was stopped due to marked leukopenia, and treatment with intravenous infl iximab was started at a dose of 3 mg/kg every 2 weeks, with an a...

Prurigo nodularis is a chronic condition characterized by a papulonodular pruriginous eruption of unknown aetiology. This condition is a difficult disease to treat and causes frustration to both the patient and the treating doctor. A variety of systemic conditions have been reported to be associated with prurigo nodularis. The mechanism by which these disorders may trigger prurigo nodularis is ...

BACKGROUND There are no studies on contact allergy in patients with prurigo. With itch being important in the pathophysiology of prurigo diseases and being a symptom of allergic contact dermatitis, we aimed to investigate contact allergy in patients suffering from prurigo. OBJECTIVES Exploratory analysis of patch test results in prurigo patients. MATERIALS AND METHODS A retrospective analys...

A large percentage of patients with HIV/AIDS will develop dermatological complications. Consequently, all practising clinicians and pathologists in regions with a high prevalence of HIV/AIDS must be familiar with the diverse cutaneous manifestations of the disease. This paper highlights the fact that biopsy material in this clinical context may occasionally reveal more than one pathological pro...

Prurigo is a common, but treatment-resistant, skin disease characterized by persistent papules/nodules and severe itching. Prurigo occurs in association with various underlying diseases, such as diabetes, chronic renal failure, and internal malignancies. Atopic dermatitis is occasionally complicated by prurigo lesions. However, the pathology of prurigo is completely undefined. We demonstrate th...

BACKGROUND Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4. OBJECTIVES To examine the association of serum IgE levels and the clinical severity of injuries. METHODS This case-control stud...