BACKGROUND The hemoglobin threshold for transfusion of red blood cells in patients with acute gastrointestinal (GI) bleeding is controversial. We compared the efficacy and safety of a restrictive transfusion strategy with those of a liberal transfusion strategy. METHODS OBJECTIVE The objective was to prove that the restrictive threshold for red blood cell transfusion in patients with acute...

OBJECTIVE To assess the drug prescription service in a dental clinic of a Mexican university hospital. METHOD An observational, descriptive study was carried out which analysed 698 drugs prescribed for dental problems in 14 dental health care departments in our clinic between the period of January-June 2005. The following criteria were established: prescribed drug, indication, dosage, dosage ...

Preformulation studies on transdermal dosage forms involve liberal use of animal skin for assessing the permeation characteristics of drugs, influence of permeation enhancers, optimizing the formulation variables etc. The restricted availability of animal skin due to concerns regarding prevention of cruelty to animals has generated considerable interest in developing polymeric films for use as ...

Preformulation studies on transdermal dosage forms involve liberal use of animal skin for assessing the permeation characteristics of drugs, influence of permeation enhancers, optimizing the formulation variables etc. The restricted availability of animal skin due to concerns regarding prevention of cruelty to animals has generated considerable interest in developing polymeric films for use as ...

The beta-adrenoceptor-blocking and class III effects of sotalol were assessed in 11 patients with inducible orthodromic reciprocating tachycardia. Serum sotalol concentration, maximum exercise heart rate, and electrophysiologic study data were obtained at control, at the beta-adrenoceptor-blocking dosage (407 +/- 149 mg/day, 1.4 +/- 0.5 micrograms/ml), and at the maximum well-tolerated dosage (...

since the introduction of our local manufacturing of terfenadine, we have observed and expressed our concern about a small but increasing number of serious ventricular arrhythmias associated with the use of this non sedating antihistamine. in january 1997 a case of torsade de pointes ventricular tachycardia was detected in a previously healthy woman taking terfenadine with erythromycin. electro...

Political parties are important for the functioning and consolidation of democracy – citizens should defend their rights against with agendas that conflict principles liberal types actions permissible depends on conditions political legitimacy closeness to power non-liberal-democratic theories both (un-)civil disobedience violent self-defence relevant here

A prolonged QTc interval is, among other, a predictor of sudden cardiac death. Many cardiac and non-cardiac marketed drugs prolong ventricular repolarization and have the potential to induce life-threatening ventricular tachyarrhythmias. It is generally recognized that some individuals are more susceptible than others to the QT-prolonging effects of drugs even at standard dosage regimen (geneti...