Let M be a complete Riemannian manifold and D : C∞ 0 (E) → C∞ 0 (F ) a first order differential operator acting between sections of the hermitian vector bundles E, F . Moreover, let V : C∞(E) → L∞ loc (E) be a self–adjoint zero order differential operator. We give a sufficient condition for the Schrödinger operator H = DD + V to be essentially self–adjoint. This generalizes recent work of I. Ol...