Toxicity tests are commonly used as a tool to determine the standards of water quality for chemicals and to discover appropriate organisms as bioindicators in toxicological studies, and also could be used as an essential tool for evaluation of the pollutant effects in aquatic ecosystems. The aim of the present study was to evaluate the sensitivity of two Caspian fish species, Caspian trout as a...

Nonylphenol is a metabolic intermediate from the microbial transformation of detergents used worldwide. While nonylphenol shows some acute toxicity, it is also able to mimic important hormones resulting in the disruption of several processes by interfering with the signals that control the overall physiology of the organism. This work perform a critical reviews on the origin, environmental fate...

Many kinds of endocrine-disrupting chemicals (EDCs), for example, the environmental estrogens bisphenol A and nonylphenol, may regulate the activity of estrogen receptor α (ERα) and therefore induce potential disruption of normal endocrine function. However, the involvement of EDCs in human cancers, especially in endocrine-related cancer neuroblastoma regulation, is not very clear. In this work...

Addition of surfactants, detergents and emulsifiers has been successfully applied for cleanup of petroleum-contaminated sites. However, a certain groupof widely used alkylphenolethoxylates (APEs) surfactants was recently banned in Europe because scientists discovered that APE breakdown products are estrogenic and highly toxic to aquatic organisms. Nonylphenol is one of the very toxic breakdown ...

Substantial research is currently focused on the toxicological effects of alkylphenol ethoxylates (APEs) and alkylphenols (APs) on aquatic animals. Considerable data are available on the concentrations of APEs and APs in river systems in the United States; however, few if any data are available on the tissue concentrations of fish living in these rivers. A reliable method for the analysis of no...

Although nonylphenol is known to have estrogenic effects in aquatic biota, little is known about the exposure of nonylphenol ethoxylates to insectivorous birds. This two-year study examined reproductive success, growth and immunological endpoints in Tree Swallows (Tachycineta bicolor) potentially exposed to nonylphenol and other contaminants located in sewage lagoons at a wastewater treatment p...

Nonylphenol belongs to the most investigated xenohormones acting at the estrogen receptor. Technical nonylphenol contains approximately 20 para-substituted isomers. Because of limitations in testing and quantifying all 20 isomers in the mixture, the linear form, 4n-NP, is often used as a reference substance, even though it is not present in the technical mixture. Here, we report on the synthesi...

Contaminant exposure in aqueous systems typically involves complex chemical mixtures. Given the large number of compounds present in the environment, it is critical to identify hazardous chemical interactions rapidly. The present study utilized a prototype for a novel high-throughput assay to quantify behavioral changes over time to identify chemical interactions that affect toxicity. The indep...

BACKGROUND: Xenoestrogens and antifungal azoles probably share a common route of metabolism, through hepatic cytochrome P450 (CYP) enzymes. Chemical interactions with metabolic pathways may affect clearance of both xenobiotics and endobiotics. This study was carried out to identify possible chemical interactions by those substances on CYP1A and CYP3A, in Atlantic cod liver. We investigated effe...

Aerobic biodegradation behavior of nonylphenol propoxylates was investigated using dispersive liquid-liquid microextraction as a simple and fast technique for sample preparation. The developed method proved to be efficient for the isolation and concentration of nonylphenol propoxylates before their quantification with the use of high performance liquid chromatography. The primary biodegradation...