Ca sensitization of vascular smooth muscle (VSM) contraction involves Rho-dependent and Rho-kinase– dependent suppression of myosin phosphatase activity. We previously demonstrated that excitatory agonists in fact induce activation of RhoA in VSM. In this study, we demonstrate a novel Ca -dependent mechanism for activating RhoA in rabbit aortic VSM. High KCl-induced membrane depolarization as w...

Background. The present analysis of patients with aneurismal subarachnoid hemorrhage addresses the question of how far systemically administered energy substrates or medication during intensive care management can significantly influence cerebral metabolism and must therefore be considered when interpreting the results of cerebral microdialysis. Methods. An intracerebral microdialysis catheter ...

Submit Manuscript | http://medcraveonline.com Abbreviations: TCAs: Tricyclic Antidepressants; SSRIs: Selective Serotonin-Reuptake Inhibitors; MAOIs: Monoamine Oxidase Inhibitors; SNRI: Serotonin-Norepinephrine Reuptake Inhibitor; PMDD: Premenstrual Dysphoric Disorder; SAD: Seasonal Affective Disorder; PMS: Premenstrual Syndrome; NE: Norepinephrine; 5-HT: 5-Hydroxytryptamine; DA: Dopamine; CNS: ...

BACKGROUND Hepatorenal syndrome (HRS) is known as development of acute renal failure in a patient who usually has advanced liver disease. The aim of the present study was to determine the safety and the efficacy of noradrenalin in comparison with midodrine-octreotide in patients with HRS. METHODS This study was registered to the Iranian Registry of Clinical trials (IRCT). This study was a sin...

Ca2+ sensitization of vascular smooth muscle (VSM) contraction involves Rho-dependent and Rho-kinase-dependent suppression of myosin phosphatase activity. We previously demonstrated that excitatory agonists in fact induce activation of RhoA in VSM. In this study, we demonstrate a novel Ca2+-dependent mechanism for activating RhoA in rabbit aortic VSM. High KCl-induced membrane depolarization as...

Psychologic distress is associated with increased lung cancer incidence and mortality. We have shown that non-small cell lung cancer (NSCLC) cells in vitro are stimulated by the cyclic AMP (cAMP)-dependent activation of cAMP-responsive element binding protein (CREB) and extracellular signal-regulated kinase (ERK) downstream of β-adrenergic receptors and that this pathway is inhibited by the neu...

DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalconecompound. In this study, its antidepressant-like activity of compound DHIPC was evaluated bythe forced swimming test and the tail suspension test in mice. The results showed that DHIPCsignificantly reduced the immobility time for 2 h after treatment through the oral administrationat dose of 10, 20, and 30 mg/kg in th...