BACKGROUND Noninvasive techniques for detecting acute cardiac transplant rejection are limited. We hypothesized that ultrasound contrast microbubbles targeted to the endothelial cell (EC) inflammatory marker intercellular adhesion molecule-1 (ICAM-1) would selectively bind to rejecting versus nonrejecting myocardium and that myocardial contrast echocardiography can therefore detect acute reject...

ated aging. J Gerontol Biol Sci 49:B245. Klinger MM, MacCarter GD, Boozer CN. 1996. Body weight and composition in the Sprague Dawley rat: Comparison of three outbred sources. Lab Anim Sci 46:67-70. Lipman RD, Chrisp CE, Hazzard DG, Branson RT. 1996. Pathologic characterization of Brown Norway, Brown Norway X Fischer 344, and Fischer 344 X Brown Norway rats with relation to age. J Gerontol Biol...

ated aging. J Gerontol Biol Sci 49:B245. Klinger MM, MacCarter GD, Boozer CN. 1996. Body weight and composition in the Sprague Dawley rat: Comparison of three outbred sources. Lab Anim Sci 46:67-70. Lipman RD, Chrisp CE, Hazzard DG, Branson RT. 1996. Pathologic characterization of Brown Norway, Brown Norway X Fischer 344, and Fischer 344 X Brown Norway rats with relation to age. J Gerontol Biol...

Central Eastern Asia, foremost the area bordering northern China and Mongolia, has been thought to be the geographic region where Norway rats (Rattus norvegicus) have originated. However recent fossil analyses pointed to their origin in southern China. Moreover, whereas analyses of fossils dated the species' origin as ∼ 1.2-1.6 million years ago (Mya), molecular analyses yielded ∼ 0.5-2.9 Mya. ...

An orthotopic penetrating keratoplasty model was developed in the rat. An oversized (0.5 mm) graft was used and 8 interrupted sutures were applied. These sutures were not removed. Eleven grafts out of 13 were rejected by the 3rd week in the disparate group (Brown Norway rat to Lewis rat transplantation group), which was characterized by edema, opacity, and neovascularization. All grafts remaine...

Many researchers assume that laboratory rats have poor vision, and accordingly, that they need not consider differences in the visual function of rats as a consequence of strain or experience. Currently, it is not specifically known whether rat domestication has negatively affected the visual function of laboratory rat strains, what the effects of strain albinism are on rat visual function, or ...

The aim of this research was to identify the molecular bases of differences in sensitivity to corticosteroid hormones between Brown Norway and Fischer 344 rats. We previously showed an apparent insensitivity to adrenalectomy in Brown Norway rats. Based on our first hypothesis of a different activity/reactivity of the mineralocorticoid signaling pathway between the two rat strains, we sequenced ...

Responsibilities they are given in relation to rat care and management. 3 Handling rats for routine husbandry should not be linked with ie neither proceed.R. rattus black rat is less aggressive than Norway rats and have been replaced by. Published reports of nutritional and breeding research. Neuroanatomical.HUSBANDRY STANDARDS FOR KEEPING NAKEDMOLE RATS IN. PDF created with pdfFactory trial ve...