BACKGROUND AND PURPOSE Neutrophil serine proteases (NSPs) are activated by dipeptidyl peptidase 1 (DPP1) during neutrophil maturation. The effects of neutrophil turnover rate on NSP activity following DPP1 inhibition was studied in a rat pharmacokinetic/pharmacodynamic model. EXPERIMENTAL APPROACH Rats were treated with a DPP1 inhibitor twice daily for up to 14 days; NSP activity was measured...

Combustion-derived and synthetic nano-sized particles (NSP) have gained considerable interest among pulmonary researchers and clinicians for two main reasons. 1) Inhalation exposure to combustion-derived NSP was associated with increased pulmonary and cardiovascular morbidity and mortality as suggested by epidemiological studies. Experimental evidence has provided a mechanistic picture of the a...

Nanosilicate platelets (NSP), the form of natural silicate clay that was exfoliated from montmorillonite (MMT), is widely used as a feed additive for its high non-specific binding capacity with mycotoxins such as fumonisin B1 (FB1), and has been evaluated its safety for biomedical use including cytotoxicity, genotoxicity, and lethal dosage (LD). In the study, we further examined its toxicity on...

Accepted: 02/03/2015 Abstract Polysaccharides are macromolecules of monosaccharides linked by glycosidic bonds. Polysaccharides are widespread biopolymers, which quantitatively represent the most important group of nutrients in feed. These are major components of plant materials used in rations for monogastrics. Non-starch polysaccharides (NSP) contain ß-glucans, cellulose, pectin and hemicellu...

This study was conducted to evaluate the synergistic effect of NSP enzymes and synbiotics supplementation in a cornsoybean meal based low energy diet. A total of 150 broilers were allocated to five treatment groups. Supplementation of NSP enzymes and synbiotics significantly (P<0.05) improved weight gain and FCR. The BD supplemented with NSP enzymes and synbiotics alone or in combination had no...

This study was conducted to identify the factors associated with Neck/Shoulder Pain (NSP) in Korean young adults. A self-administered questionnaire including the presence of NSP and demographic, behavioral, and psychological factors was given to 212 young adults. The data were analysed by mean, standard deviation, chi-squared test, and logistic regression. The prevalence of NSP was 81.6%. The f...

BACKGROUND School teachers represent an occupational group among which there appears to be a high prevalence of neck and/or shoulder pain (NSP) and low back pain (LBP). Epidemiological data on NSP and LBP in Chinese teachers are limited. The aim of this study was to investigate the prevalence of and risk factors for NSP and LBP among primary, secondary and high school teachers. METHODS In a c...

Thirty-five gilts grown between 18 and 55 kg live weight were used to examine the effects of feeding fermentable carbohydrate on voluntary food intake, performance, carcass characteristics, and large intestinal growth. Five diets were used. The first diet contained steam-flaked sorghum and a supplement based on animal protein sources and 40 g!kg soya-bean meal (diet SAP). Using this diet as a b...

The present study aimed to isolate and characterize side population (SP) cells in the human lung cancer A549 cell line, and elucidate the molecular mechanism of SP cells underlying lung cancer. The SP and non-SP (NSP) cells in A549 cells were isolated and their differentiation was analyzed by fluorescence-activated cell sorting. An in vitro plate clone assay, Matrigel® Transwell assay and chemo...

In this study, dairy cows were treated with calcium montmorillonite clay (NSP; BASF Corp., Ludwigshaven, Germany) in a replicated 5x5 Latin square design. The primary objectives were to determine if milk composition was altered following ingestion of NSP, and to investigate the ability of NSP to reduce aflatoxin (AF) transfer to milk with the inclusion of low doses in the diet (concentrations e...