Obsessive-compulsive disorder is a chronic and disabling condition that often proves to be treatment resistant. Of the patients suffering from obsessive-compulsive disorder, 10%-27% may attempt suicide at least once in their life. We report the case of a patient who presented severe obsessive-compulsive disorder symptoms and attempted suicide ingesting 25 tablets of fluoxetine (20 mg). The pati...

Development of obsessive-compulsive symptoms during clozapine treatment in schizophrenics has been noted in few reports from west. In our cases, three schizophrenic patients resistant to typical antipsychotics developed obsessive-compulsive symptoms during clozapine treatment. Since clozapine is a potent 5-HT(2) receptor blocker, role of serotonergic systems in the development of obsessive-comp...

Obsessive compulsive symptoms have been reported to occur in high proportion in schizophrenia. Presence of obsessive compulsive symptoms in schizophrenia has poor prognostic significance. Because of the antiobsessional effect of the fluoxetine, present study was undertaken as preliminary investigation in cases of schizophrenia with obsessive compulsive symptoms. We conducted an open trial of 12...

Objective: The present study describes the process of translation into Brazilian Portuguese and the cross-cultural adaptation of the Obsessive-Compulsive Inventory and the Obsessive-Compulsive Inventory-Revised scales. The Obsessive-Compulsive Inventory was developed with the purpose of measuring the intensity of the various symptoms that characterize the obsessive-compulsive disorder, assessin...

Neuroimaging studies have indicated abnormalities in cortico-striato-thalamo-cortical circuits in obsessive-compulsive disorder patients, but results have not been consistent. Since there are significant sex differences in human brain anatomy and obsessive-compulsive symptomatology and its developmental trajectories tend to be distinct in males and females, we investigated whether sex is a pote...

Neuroimaging studies of obsessive-compulsive disorder have found abnormalities in orbitofronto-striato-thalamic circuitry, including the orbitofrontal cortex, anterior cingulate cortex, caudate, and thalamus, but few studies have explored abnormal intrinsic or spontaneous brain activity in the resting state. We investigated both intra- and inter-regional synchronized activity in twenty patients...

OBJECTIVE There is little information about obsessive-compulsive disorder in large representative community samples. The authors aimed to establish obsessive-compulsive disorder prevalence and its clinical typology among adults in private households in Great Britain and to obtain generalizable estimates of impairment and help-seeking. METHOD Data from the British National Psychiatric Morbidit...

BACKGROUND Mental health professionals observed booming in prevalence of obsessive compulsive symptoms among children and adolescents. Our epidemiological study aims at estimating the prevalence of obsessive symptoms and obsessive compulsive disorder among secondary school students and, as a secondary research objective, to assess religious attitudes among those patients. MATERIALS The study ...

OBJECTIVE To update clinicians regarding the existence of a putative subtype of obsessive-compulsive disorder based on poor insight. METHOD Opinionative review based on studies indexed in the PubMed and PsychINFO databases, identified by means of the keywords 'obsessive-compulsive disorder' AND 'insight' OR 'ego-syntonic', and published between 1966 and October 2009. The results were analyzed...