Amphetamine withdrawal increases anxiety and stress sensitivity related to blunted ventral hippocampus (vHipp) and enhances the central nucleus of the amygdala (CeA) serotonin responses. Extracellular serotonin levels are regulated by the serotonin transporter (SERT) and organic cation transporter 3 (OCT3), and vHipp OCT3 expression is enhanced during 24 hours of amphetamine withdrawal, while S...

Embryonic stem (ES) cells are immortal and pluripotent cells derived from early mammalian embryos. Transcription factor Oct3/4 is essential for self-renewal of ES cells and early mouse development. However, only a few Oct3/4 target genes have been identified. In this study, we found that F-box-containing protein Fbx15 was expressed predominantly in mouse undifferentiated ES cells. Inactivation ...

objective(s): organic cation transporter 3 (oct3) as a high-capacity transporter contribute to the metabolism of metformin. the present study was conducted to determine the genotype frequencies of the variant oct3-1233g>a (rs2292334) in patients with newly diagnosed type 2 diabetes (t2d) and its relationship with response to metformin. materials and methods: this study included 150 patients wit...

Organic cationic transporter 3 (OCT3, SLS22A3) has only recently emerged as one of the regulators of monoaminergic neurotransmission, which plays a critical role in the pathogenesis of depression and is a potential new antidepressant drug target. OCT3 single-nucleotide polymorphisms (SNPs) have been investigated for their association with psychiatric disorders such as methamphetamine use disord...

Toxic organic cations can damage nigrostriatal dopaminergic pathways as seen in most parkinsonian syndromes and in some cases of illicit drug exposure. Here, we show that the organic cation transporter 3 (Oct3) is expressed in nondopaminergic cells adjacent to both the soma and terminals of midbrain dopaminergic neurons. We hypothesized that Oct3 contributes to the dopaminergic damage by bidire...

The aim of the present study was to investigate the expression, localization, and function of organic cation transporter 3 (Oct3, Slc22a3) and multidrug and toxin extrusion protein 1 (Mate1, Slc47a1) in the rat placenta. Using qRT-PCR and Western blotting techniques, we demonstrated abundant Oct3 and Mate1 mRNA and protein expression achieving significantly higher levels than those in the mate...

Gastrulation is characterized by the differentiation of pluripotent cells to generate the germ layers, morphogenetic movements, a decrease in cell proliferation and establishment of the embryonic axes. We show by Cdx1 knock-down that it functions as a regulator of the onset of gastrulation in agreement with its early expression. In a microarray-based approach to search for Cdx1 targets, we iden...

Gastrulation is characterized by the differentiation of pluripotent cells to generate the germ layers, morphogenetic movements, a decrease in cell proliferation and establishment of the embryonic axes. We show by Cdx1 knock-down that it functions as a regulator of the onset of gastrulation in agreement with its early expression. In a microarray-based approach to search for Cdx1 targets, we iden...

Germ cell tumors show many similarities to normal embryogenesis. This is, for example, illustrated by the expression of the marker of pluripotency, OCT3/4, known to play a pivotal role in the early stages of normal development. Interestingly, it is found to be the most informative diagnostic marker for the early developmental stages of malignant germ cell tumors. Expression regulation of OCT3/4...

Gastrulation is characterized by the differentiation of pluripotent cells to generate the germ layers, morphogenetic movements, a decrease in cell proliferation and establishment of the embryonic axes. We show by Cdx1 knock-down that it functions as a regulator of the onset of gastrulation in agreement with its early expression. In a microarray-based approach to search for Cdx1 targets, we iden...