The hydroxyapatite (HAP) with variable chemical substitutions has been considered as the major component in the mineralized part of bones. Various metastable crystalline phases have been suggested as transitory precursors of HAP in bone, but there are no consensuses as to the nature of these phases and their temporal evolution. In the present study, we cultured rat calvarial osteoblasts with as...

Although the efficacy of the in vivo osteogenic capabilities of synthetic octacalcium phosphate (OCP) crystal implantation can be explained through its stimulatory capacity for the differentiation of the host osteoblastic cell lineage, direct evidence that OCP supports bone regeneration by osteogenic cells in vivo has not been shown. Mesenchymal stem cells (MSCs) isolated from 4-week-old male W...

What are biominerals and how are they formed? It is usually assumed: (i) that the prototype for most apatitic biominerals is hydroxyapatite (OHAp), Ca5(PO4)3OH; and (ii) that the OHAp structure has been modified by the presence of impurity ions and vacancy defects in specific OHAp lattice sites. The usual answer, at least implicitly, to the second question is that the apatitic mineral is formed...

Calcium phosphate is attracting attention as a bone repair material and controlled-release carrier of various drugs such disease therapeutic agents anticancer agents. Compared with some bioabsorbable polymers, calcium phosphates have the advantage preventing pH decrease in surrounding body fluid. However, there are few studies comparing effect supporting substances different physicochemical pro...

Statement of problem: It is not known whether endochondral and intramembranous bones have distinct biological characteristics. Octacalcium Phosphate (OCP), a hydroxyapatite precursor, has been reported to stimulate bone formation after being implanted in parietal bone defects of rats. Purpose: The present study was designed to investigate the response of endochondral and intramembranous bones t...

Herein, we show that the enhanced osteogenecity of octacalcium phosphate (OCP) biomaterial, recently identified as an important element in hybrid organic–inorganic nanocomposites involved initial hydroxyapatite crystal expansion mammal bones, results from chemical property, stemming presence lattice strain and dislocations. Two types OCPs were synthesized by wet-chemical processing (c-OCP) abse...

Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawle...

63 Introduction Bone defects attributed to serious periodontitis, trauma, and injury are commonly encountered in the fields of dentistry, craniofacial surgery, and orthopedics. Although autogenous bone grafting is still considered the gold standard for treatment, this process has several drawbacks, such as the requirement of a second surgery and the limited availability of collectable bone [1]....

A novel, one-pot technique of synthesizing calcium phosphate whiskers was developed. Commercially available b-tricalcium phosphate (b-Ca3(PO4)2) powders were aged in unstirred 30% H2O2 solutions at 901C for 48 h in ordinary glass media bottles. Resultant samples consisted of whiskers (200 nm wide and 5 lmlong) of a biphasic mixture of octacalcium phosphate (OCP: Ca8H2(PO4)6 . 5H2O) and carbonat...