oft

Cardiac outflow tract (OFT) septation is crucial to the formation of the aortic and pulmonary arteries. Defects in the formation of the OFT can result in serious congenital heart defects. Two cell populations, the anterior heart field (AHF) and cardiac neural crest cells (CNCCs), are crucial for OFT development and septation. In this study, we use a series of tissue-specific genetic manipulatio...

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An Nkx2-5/Bmp2/Smad1 Negative Feedback Loop Controls Heart Progenitor Specification and Proliferation

Journal: :Cell 2007

Owen W.J. Prall Mary K. Menon Mark J. Solloway Yusuke Watanabe Stéphane Zaffran Fanny Bajolle Christine Biben Jim J. McBride Bronwyn R. Robertson Hervé Chaulet Fiona A. Stennard Natalie Wise Daniel Schaft Orit Wolstein Milena B. Furtado Hidetaka Shiratori Kenneth R. Chien Hiroshi Hamada Brian L. Black Yumiko Saga Elizabeth J. Robertson Margaret E. Buckingham Richard P. Harvey

During heart development the second heart field (SHF) provides progenitor cells for most cardiomyocytes and expresses the homeodomain factor Nkx2-5. We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract (OFT) morphology. In the cardiac fields of Nkx2-5 mutants, genes controlling cardiac specification (including Bmp2) and ...

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