background: in the recent years nanostructured materials have been the focus of researches due to their wide-spread possibilities to provide new shapes and structures for some materials. microemulsions can provide uniform nano-sized droplets for templating. microemulsions are isotropic, thermodynamically-stable systems of oil, water and surfactant with a 20-200 nm droplet size. they can be prep...

A detailed characterization of the microemulsion composition is necessary to make the phosphorimetry suitable as powerful analytical methodology. Four microemulsion systems (hexane/n-butanol/SDS/water, hexane/n-pentanol/SDS/water, hexane/3-pentanol/SDS/ water, and hexane/n-hexanol/SDS/water) were studied, establishing the oil/water (O/W) microemulsion composition with best phosphorimetric chara...

The objective of the present study was to design and develop a microemulsion based transungual drug delivery formulation of ciclopirox olamine using colloidal carrier for treatment of onychomycosis. Capmul PG8 was selected as oil phase due to the high solubility of ciclopirox in it as compared to other oils and Cremophor EL and Transcutol P were used as surfactant and cosurfactant respectively....

The structure-activity relationship of a U-type antimicrobial microemulsion system containing glycerol monolaurate and ethanol at a 1∶1 mass ratio as oil phase and Tween 20 as surfactant were investigated along a water dilution line at a ratio of 80∶20 mass% surfactant/oil phase, based on a pseudo-ternary phase diagram. The differential scanning calorimetry results showed that in the region of ...

Microemulsions are dispersions of water and oil stabilized by one or mixtures of surfactants. The key differentiators from other dispersions are: (i) domain size of the dispersed phase is of the order of 5-100 nm in size (Schulmann et al., 1959); (ii) thermodynamically stable (Zana, 1994), and (iii) optically isotropic (Danielsson and Lindman, 1981). Commonly observed structures are: oil in wat...

The Essential oil (EO) of Nigella sativa (black cumin) was extracted from the crude oil and the volatile constituents were characterized using gas chromatographic analysis. The EO was formulated in water-based microemulsion system and its antibacterial activity against six pathogenic bacteria was evaluated using the agar well diffusion method. This activity was compared with two other well know...

In this study the effect of temperature, NaCl and oils (hydrocarbons: C(8)-C(16)) on the formation and solubilization capacity of the systems of oil/monoacylglycerols (MAG):ethoxylated fatty alcohols (CEO(20))/propylene glycol (PG)/water was investigated. The effects of the surfactant mixture on the phase behavior and the concentration of water or oil in the systems were studied at three temper...

objective(s):investigation of phase diagram of various drug formulations is effective to predict different phase region of drugs to detect final formula. the purpose of this research was to develop the ternary phase diagrams for a drug microemulsion system consisting of cucurbita pepo (pumpkin) oil, surfactant (tween 80) and deionized water. materials and methods:an electrical conductivity was ...

Mixing two immiscible liquids (such as oil and water) using emulsifier and energy inputs has been the matter of study for decades. In early 1890’s extensive work have been carried out on macroemulsions (i.e. oil dispersed in water in the form of fine droplets or vice versa) (Becher, 1977) and several theories and methods of their formation have been vastly explored (Lissant 1976 and 1984). Howe...

BACKGROUND A microemulsion is an effective formulation for improving the oral bioavailability of poorly soluble drugs. In this paper, a water-in-oil (w/o) microemulsion was investigated as a system for enhancing the oral bioavailability of Biopharmaceutic Classification System (BCS) III drugs. METHODS The microemulsion formulation was optimized using a pseudoternary phase diagram, comprising ...