The topological architecture and functions of different cells of the olfactory epithelium in Wallago attu (Bleeker) have been systematically studied using a scanning electron microscope. The elongated olfactory rosette of the fish consists of 62 to 64 primary lamellae in each left and right rosette. Each lamella is provided with apical sensory epithelium and basal non-sensory epithelium. Topolo...

Mammalian olfactory receptor families are segregated into different olfactory organs, with type 2 vomeronasal receptor (v2r) genes expressed in a basal layer of the vomeronasal epithelium. In contrast, teleost fish v2r genes are intermingled with all other olfactory receptor genes in a single sensory surface. We report here that, strikingly different from both lineages, the v2r gene family of t...

Although the function of the adult olfactory system has been thoroughly studied, the molecular mechanisms regulating the initial formation of the olfactory nerve, the first cranial nerve, remain poorly defined. Here, we provide evidence that both modulated Notch and bone morphogenetic protein (BMP) signaling affect the generation of neurons in the olfactory epithelium and reduce the number of m...

The olfactory epithelium of Scatophagus argus (Linnaeus) was investigated by light and scanning electron microscopy. The elongated olfactory organ is made up of 20 to 22 primary lamellae arranged on both sides of the narrow median raphe. Sensory and non-sensory regions are located separately on each lamella. The sensory epithelium occupies the upper apical broad half and extreme basal part of t...

Axonal development and synapse formation in olfactory sensory neurons By Florencia Marcucci The olfactory epithelium (OE) possesses the rare capacity among neuronal tissues to regenerate throughout life. As a result, progenitor cells continuously proliferate and differentiate into olfactory sensory neurons (OSNs) that project their axons to the olfactory bulb (OB) where they establish connectio...

The developmental expression of immunocytochemical reactivity to 3 monoclonal antibodies (Mabs Neu 4, Neu 5, and Neu 9) that were generated against adult rat olfactory epithelium was examined in olfactory tissues of embryonic rats. Tissues examined included the nasal olfactory epithelium, nerve, and olfactory bulb, as well as vomeronasal epithelium and nerve. Reactivity patterns of these Mabs i...

Intestinal epithelium development is dramatically impaired in germfree rodents, but the consequences of the absence of microbiota have been overlooked in other epithelia. In the present study, we present the first description of the bacterial communities associated with the olfactory epithelium and explored differences in olfactory epithelium characteristics between germfree and conventional, s...

Tic h Y F., D. H 0 r k y, I. M i ~ e k: Differentiation of the Olfactory Epithelium in Sheep in Ontogenesis using Scanning Electron Microscopy. Acta vet. Bmo 1995, 64:71-77. The method of scanning electron microscopy was used to study the differentiation of the olfactory epithelium and the formation of the surface of the olfactory epithelium of sheep on the 74th and 79th days of prenatal period...

The Ca(2+)-activated Cl(-) channel is considered a key constituent of odor transduction. Odorant binding to a specific receptor in the cilia of olfactory sensory neurons (OSNs) triggers a cAMP cascade that mediates the opening of a cationic cyclic nucleotide-gated channel (CNG), allowing Ca(2+) influx. Ca(2+) ions activate Cl(-) channels, generating a significant Cl(-) efflux, with a large cont...

Traditionally, the olfactory epithelium is considered to recognize conventional odors, while the vomeronasal organ detects pheromones. However, recent advances suggest that vertebrate pheromones can also be detected by the olfactory epithelium. In the vomeronasal organ and the olfactory epithelium, structurally distinct multiple receptor families are expressed. In rodents, two of these receptor...