Intraventricular oligodendrogliomas are a rare subset of oligodendrogliomas. Analysis of the clinical and CT characteristics of 11 cases in the literature and eight new examples revealed specific radiographic features, which included the presence of an anterior, midline mass within the lateral ventricles composed of clumped calcifications within a dense, enhancing matrix. Hydrocephalus is a con...

Aims/Background—Telomerase is an enzyme that is expressed in most human neoplasms and is associated with tumour immortality. Determination of the point in neoplastic transformation at which telomerase is expressed may aid the understanding of tumour pathogenesis and progression.Despite numerous reports on telomerase, few studies have investigated its expression in high grade glial tumours. Thes...

AIMS/BACKGROUND Telomerase is an enzyme that is expressed in most human neoplasms and is associated with tumour immortality. Determination of the point in neoplastic transformation at which telomerase is expressed may aid the understanding of tumour pathogenesis and progression. Despite numerous reports on telomerase, few studies have investigated its expression in high grade glial tumours. The...

Pilocytic astrocytoma (WHO grade I) is a circumscribed, slowly growing, benign astrocytoma that most frequently develops in the cerebellar hemispheres and in midline structures and occurs predominantly in childhood and adolescence. In contrast to diffusely infiltrating gliomas in adults (e.g. grade II astrocytomas, oligodendrogliomas), survival of patients with pilocytic astrocytoma is excellen...

In this issue of Clinical Cancer Research, Walker et al. (1) report a comprehensive analysis of metabolic rate, tumor grade, contrast enhancement, and molecular genetic alterations in oligodendrogliomas and oligoastrocytomas. Brain tumor metabolism was assessed by single-photon emission computed tomography (SPECT) using two radiolabeled tracers, thallium (Tl) and [F]fluorodeoxyglucose (FDG). Tl...

Oligodendrogliomas are the second most common type of glial neoplasm with distinct prognostic and therapeutic implications. Although refinements have led to improved clinical stratification, current grading schemes are still limited by subjective histopathological criteria. In this report, we have used oligonucleotide array technology to perform expression profiling in morphologically classic o...

El perfil molecular de los gliomas permite garantizar la precisión del diagnóstico, informar el pronóstico e identificar opciones tratamiento. Esta revisión tiene como objetivo exponer que con secuenciación próxima generación (NSG) diagnóstico pacientes oligodendrogliomas puede ser más exacto. Además, un dispositivo in vitro, basado en NSG (F1CDx), se utilizan bloques parafina para analizar has...