A quantitative analysis of the effects of nonlinearity in an open loop amplifier on the linearity of negative feedback amplifiers is presented. Results show that the ratio of the open-loop nonlinearity (OLN) to the closedloop nonlinearity (CLN) in the presence of varying amounts of secondand third-order nonlinearities in the open loop amplifier is quantified. Results show that for the same amou...

Ohio, like other states, faces the challenges of enhancing its educational infrastructure in order to increase the ability of its educational institutions to collaborate on degree programs and provide distance education to support life long learning. Delivering educational materials from higher education institutions to K-12 schools and to provide a means for collaborative higher education prog...

Tau-positive inclusions in oligodendrocytes are consistent neuropathological features of corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementias with Parkinsonism linked to chromosome 17. Here we show by immunohistochemistry that tau-positive oligodendroglial inclusion bodies also contain the small heat-shock protein (HSP) alphaB-crystallin but not HSP70. To stud...

Background. The efficacy, safety, and cost benefit of olanzapine (OLN) when compared to aprepitant (APR) in the prevention of chemotherapy induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC) were evaluated. Methods. A prospective pilot study was done in chemotherapy-naive patients receiving HEC to compare OLN versus APR along with palonosetron and dexam...

THE electrocardiogram of presumably normal infants and children has been the subject of extensive investigation.''2 On the other hand, an extensive review of the literature failed to reveal reports of the electrocardiograms of infants and children suffering from pulmonary disease.'3' 14 Ziegler12 in 1951 recorded the electrocardiograms of normal inifants and children ranging in age from birth t...

We discuss properties and values of maximum matchings and minimum median problems for nite point sets. In particular, we consider \minimum stars", which are deened by a choosing a center, such that the total geometric distance to all the points in the set is minimized. Since the center point is not required to be an element of the set (i. e., the center may be a Steiner point), we get a \minimu...

We consider the problem of traveling the contour of the set of all points that are within distance 1 of a connected planar curve arrangement P, forming an embedding of the graph G. We show that if the overall length of P is L, there is a closed roundtrip that visits all points of the contour and has length no longer than 2L + 2. This result carries over in a more general setting: if R is a comp...

α-Synuclein (α-syn) positive glial cytoplasmic inclusions (GCI) originating in oligodendrocytes (ODC) are a characteristic hallmark in multiple system atrophy (MSA). Their occurrence may be linked to a failure of the ubiquitin proteasome system (UPS) or the autophagic pathway. For proteasomal degradation, proteins need to be covalently modified by ubiquitin, and deubiquitinated by deubiquitinat...

BACKGROUND The accumulation and aggregation of alpha-synuclein in nerve cells and glia are characteristic features of a number of neurodegenerative diseases termed synucleinopathies. alpha-Synuclein is a highly soluble protein which in a nucleation dependent process is capable of self-aggregation. The causes underlying aggregate formation are not yet understood, impairment of the proteolytic de...