نتایج جستجو برای: oncogenic and suppressor micro rnas mirnas

تعداد نتایج: 16867345  

Journal: :Frontiers in bioscience 2012
Elodie Lages Helene Ipas Audrey Guttin Houssam Nesr Francois Berger Jean-Paul Issartel

microRNAs (miRNAs) are small noncoding endogenously produced RNAs that play key roles in controlling the expression of many cellular proteins. Once they are recruited and incorporated into a ribonucleoprotein complex miRISC, they can target specific mRNAs in a miRNA sequence-dependent process and interfere in the translation into proteins of the targeted mRNAs via several mechanisms. Consequent...

2012
Yoshimasa Saito Hidetsugu Saito

MicroRNAs (miRNAs) are small non-coding RNAs that regulate expression of various target genes. miRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Epigenetic alterations such as DNA methylation and histone modification are essential for chromatin remodeling and regulation of gene expression including miRNAs. The CCCTC-...

2014
Cesar Seigi Fuziwara Edna Teruko Kimura

Anaplastic thyroid cancer (ATC) is among the most lethal types of cancers, characterized as a fast-growing and highly invasive thyroid tumor that is unresponsive to surgery and radioiodine, blunting therapeutic efficacy. Classically, genetic alterations in tumor suppressor TP53 are frequent, and cumulative alterations in different signaling pathways, such as MAPK and PI3K, are detected in ATC. ...

2011
Jennifer M. Noto Richard M. Peek

Gastric carcinogenesis is a multistep process orchestrated by aberrancies in the genetic and epigenetic regulation of oncogenes and tumor suppressor genes. Chronic infection with Helicobacter pylori is the strongest known risk factor for the development of gastric cancer. H. pylori expresses a spectrum of virulence factors that dysregulate host intracellular signaling pathways that lower the th...

Journal: :international journal of hematology-oncology and stem cell research 0
amirali davoudpour institute of prophylaxy and epidemiology of cardiovascular diseases (ipek), ludwig-maximilians university, munich- germany

messenger rnas may be targeted by short 19-27 nt rnas generally called small none-coding rnas (snrnas), the role of mirnas among other snrnas has been more studied and is well known. many researches show that all compartments of risc, proteins and mirnas take part in this wide range of regulatory impacts. ago protein homologs plus mirnas and target mrnas form a silencing complex in p-bodies whi...

Abbas Yazdanbod, Esmat Abdi, Hamid Latifi-Navid, Saber Zahri, Saeid Latifi-Navid,

Gastric cancer (GC) is the second leading cause of cancer-related deaths worldwide. It has been proposed that the specific genotypes of Helicobacter pylori (H. pylori) are the causative agents in the development of gastroduodenal diseases, such as chronic atrophic gastritis, peptic ulcerations, and GC. However, disease progression to GC occurs in only a small proportion of infected patients. Re...

2015
XIAOQIANG GUO JIAZENG XIA JIANG YAN

Gastric cancer (GC) is the fourth most commonly diagnosed type of cancer worldwide and has the second highest mortality rate of all cancer types. Classical genetics alone does not fully explain how GC occurs; however, epigenetics provides a partial explanation with regard to the cause of cancer. DNA methylation, the best‑known type of epigenetic marker, represses the expression of tumor‑suppres...

Journal: :International journal of clinical and experimental medicine 2010
Qing Ji David Karnak Ping Hao Rongquan Wang Liang Xu

Emerging evidence demonstrates that both tumor suppressor and oncogenic miRNAs play an essential role in stem cell self-renewal and differentiation by negatively regulating the expression of certain key genes in stem cells. It seems logical that they may also be critical players in cancer stem cells. Though small in size, miRNAs play a key role in the epigenetic regulation of cancer stem cells....

Journal: :Türk biyokimya dergisi 2022

Abstract Objectives This study aimed to examine the role of miR-221, miR-650, and miR-4534 expressions in development, pathogenesis, early diagnosis prostate cancer. Methods The included 83 participants: 37 patients with PCa, 31 BPH, 15 healthy subjects. MiRNA plasma samples was evaluated by quantitative RT-PCR. Results Plasma miR-221 levels were significantly upregulated PCa BPH groups compare...

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