MicroRNAs (miRNAs or mirs) are small, non-coding RNAs that bind specific mRNAs and decrease their translation or increase their degradation. miRNAs may modulate the formation and maintenance of tumors by regulating oncogene and tumor suppressor expression. For example, overexpression of a subset of miRNAs has been inversely correlated with certain tumor phenotypes, suggesting a role in tumor su...

Resistance to cancer treatment is one of the major challenges currently faced when treating gastrointestinal (GI) cancers. A contributing factor this resistance presence stem cells (CSCs) in GI cancers (e.g., colorectal, pancreatic, gastric, liver cancer). Non-coding RNAs, such as microRNAs (miRNAs), have been found regulate several key targets that are responsible for stemness, and function on...

MicroRNAs (miRNAs) are a class of post-transcriptional gene expression modulators. In the past two decades, over 1500 human miRNAs were discovered. Each miRNA controls hundreds of gene targets through imperfect complimentary miRNA–mRNA binding. These small non-coding RNAs regulate various biological processes, including cell growth, proliferation, differentiation, and cell death. The correlatio...

UNLABELLED Exploring microRNA (miRNA) regulations and protein-protein interactions could reveal the molecular mechanisms responsible for complex biological processes. Mirin is a web-based application suitable for identifying functional modules from protein-protein interaction networks regulated by aberrant miRNAs under user-defined biological conditions such as cancers. The analysis involves co...

PURPOSE The potential of microRNAs (miRNAs) as novel tumor markers has been the focus of recent scrutiny because of their tissue specificity, stability, and association with clinicopathological parameters. Data have emerged documenting altered systemic miRNA expression across a spectrum of cancers; however, it remains uncertain as to whether circulating miRNAs are tumor specific. Our aim was to...

High red meat consumption is associated with increased risk of colorectal cancer. Various mechanisms have been proposed, including mutagenesis, alterations of the gut microbiome, and effects on local immunity and inflammation. This lack of well-defined mechanistic explanations for diet and cancer associations coupled with our inability to derive causal inferences from population-based studies a...