نتایج جستجو برای: onset type eoad
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INTRODUCTION One major factor that influences the heterogeneity of Alzheimer's disease (AD) is age: younger AD patients more frequently exhibit atypical forms of AD. We propose that this age-related heterogeneity can be understood better by considering age-related differences in atrophy in the context of large-scale brain networks subserving cognitive functions that contribute to memory. METH...
INTRODUCTION The purpose of the study was to analyse caregiver burden and consumption of psychosocial services in a consecutive group of patients with early onset Alzheimer's disease (EOAD) compared with a matching group with late onset Alzheimer's disease (LOAD). MATERIAL AND METHODS This was a case-control study with 42 patients who were matched according to disease severity at the time of ...
Background In healthy ageing, there is evidence of sex differences in vulnerability hippocampal subfields to volume loss. However, this has not been investigated early-onset Alzheimer’s disease (<65 years; EOAD). Method We included 106 subjects: 62 EOAD (A+T+N+, MMSE>15) and 44 controls (HC; A-T-N-) that underwent lumbar puncture for analysis AD biomarkers, 3T-MRI scan neuropsychological assess...
BACKGROUND Determinants of early-onset Alzheimer's disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation. OBJECTIVE The objective of this study was to assess the putative association between VRFs and EOAD. METHODS We studied participants with dementia meeting criteria for EOAD (recruited into the French CoMAJ pro...
Previous studies comparing early-onset Alzheimer’s disease (EOAD) and late-onset AD (LOAD) have been limited by cross-sectional design and a focus on isolated clinical variables. This study aims to explore differentials in clinical features between EOAD and LOAD and to examine longitudinally trends in cognitive function. Data from 3,747 subjects with AD from C-Path Online Data Repository was us...
Introduction: Artemisia dracunculus L. belongs to Asteraceae family, and is a medicinal plant widely used in traditional medicine as a remedy for gastrointestinal disturbances. This study was undertaken to evaluate the effects of essential oil of A. dracunculus (EOAD) on the rat alimentary tract. Methods: The EOAD was extracted by Clevenger apparatus using hydrodistillation. LD50 was calcula...
Early-onset Alzheimer's disease (EOAD) represents 1%-2% of the Alzheimer's disease (AD) cases, and it is generally characterized by a positive family history and a rapidly progressive symptomatology. Rare coding and fully penetrant variants in amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) are the only causative mutations reported for autosomal dominant AD. Thus...
Early social dysfunction is a hallmark symptom of behavioral variant frontotemporal dementia (bvFTD); however, validated measures for assessing social deficits in dementia are needed. The purpose of the current study was to examine the utility of a novel informant-based measure of social impairment, the Socioemotional Dysfunction Scale (SDS) in early-onset dementia. Sixteen bvFTD and 18 early-o...
CALHM1 is a plasma membrane voltage-gated Ca2+-permeable ion channel that controls amyloid-β (Aβ) metabolism and is potentially involved in the onset of Alzheimer's disease (AD). Recently, Rubio-Moscardo et al. (PLoS One (2013) 8: e74203) reported the identification of two CALHM1 variants, G330D and R154H, in early-onset AD (EOAD) patients. The authors provided evidence that these two human var...
Background The Longitudinal Early-onset Alzheimer Disease study (LEADS) aims to robustly characterize biomarkers of early-onset AD (EOAD). Here we quantified white matter hyperintensities (WMH) in EOAD and compared the volume WMH with that cognitively normal (CN) amyloid-negative dementia (EOnonAD) groups. Methods We 194 amyloid-positive EOAD, 59 EOnonAD, 88 participants. left right frontal, te...
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