Background: In maintenance therapy for opioid addiction, to reduce the risk of buprenorphine (BUP) abuse, the combination of BUP and naloxone (NX) has been developed and is commercially available as suboxone (BUP/NX). This study was designed to compare addiction relapse frequency in patients receiving BUP and BUP/NX as maintenance therapy. Methods: In this double-blind clinical trial with cross...

Post operative pain and its control remains one of the most important issues in the field of surgery and health care system. Formalin test has been used as a method for assessing pain and analgesia in rats. Systemic and spinally administered clonidine, an ?2-adrenergic agonist, is proved to enhance postoperative analgesia. It has also been shown that morphine-dependent rats experience more chr...

Substance use is a globally devastating social problem. Early maladaptive schemas (EMSs) are inefficient mechanisms leading directly or indirectly to psychological distress. The current study aimed to assess the role of EMSs in predicting opioid use disorder. The cross-sectional study was conducted in 2013 in Bojnurd at northeast of Iran on 60 male opioid users who received Methadone Maintenanc...

CONTEXT The rate of prescription opioid-related overdose death increased substantially in the United States over the past decade. Patterns of opioid prescribing may be related to risk of overdose mortality. OBJECTIVE To examine the association of maximum prescribed daily opioid dose and dosing schedule ("as needed," regularly scheduled, or both) with risk of opioid overdose death among patien...

background: anxiety disorders and substance abuse are commonest comorbidities among bipolar i disorder (bid) patients. this study investigated the prevalence of anxiety disorders among bid patients based on their dependency on opioid. methods: in this cross sectional study the bid patients in iranian hospital of psychiatry were divided into two 89-patient groups; one group was considered as opi...

The past decade has seen a marked increase in the illicit use of opioids, as well as a doubling of the percentage of individuals seeking treatment for opioid use disorders. However, little is known about the differences between opioid users and nonopioid users in residential treatment. Further, no studies have been published that compare opioid users and nonopioid users in treatment for co-occu...

Emerging clinical and preclinical evidence suggests that a compound displaying high affinity for μ, κ, and δ opioid (MOP, KOP, and DOP) receptors and antagonist activity at each, coupled with moderate affinity and efficacy at nociceptin opioid peptide (NOP) receptors will have utility as a relapse prevention agent for multiple types of drug abuse. Members of the orvinol family of opioid ligands...

A central question in prescribing opioids for chronic non-cancer pain (CNCP) is how to best balance the risk of opioid abuse and dependence with the benefits of pain relief. To achieve this balance, clinicians need an understanding of the risk factors for opioid abuse, an issue that is only partially understood. We conducted a secondary data analysis of regional VA longitudinal administrative d...

The most recent National Survey on Drug Use and Health showed a continuing trend in the nonmedical use of prescription medications, notably opioid analgesics, which accounted for 75% of prescription drug non-medical use in 2006. In 2006, in response to this growing “pharmacoepidemic,” the Office of National Drug Control Policy set a goal of reducing past month prescription drug abuse by 15% ove...

background substance use in patients with psychiatric disorder is an every-day seen. detection of this comorbidity can significantly affect the treatment of these disorders, as well as substance use. objectives this study has been conducted to determine the prevalence and pattern of substance use in hospitalized psychiatric patients. patients and methods in this cross-sectional study, 210 hospi...