introduction: elevated intracranial pressure (icp) is a major and potentially lethal disorder in patients admitted to the emergency department (ed). several methods are being used to investigate for elevated icp. here we assessed and compared the diagnostic accuracy of two existing tools of ophthalmoscopy and optic nerve ultrasonography in detection of elevated icp. methods: 131 participants wi...

introduction: timely diagnosis and treatment of post traumatic, elevated intracranial pressure (eicp), could reduce morbidity and mortality, as well as improve patients’ outcome. this study is trying to evaluate the diagnostic accuracy of sonographic optic nerve sheath diameter (onsd) in detection of eicp. methods: sonographic onsd of patients with head trauma or cerebrovascular accident suspic...

conclusion the study evaluated the biomechanical properties of the on and peripapillary structures in vivo with swe in glaucoma. we observed stiffer on and peripapillary tissue in glaucomatous eyes, indicating that swe claims new perspectives in the evaluation of on and peripapillary structures in glaucoma disease. background primary open-angle glaucoma is a multifactorial serious disease chara...

PURPOSE The defining feature of glaucoma is excavation of the optic nerve head; however, the mechanism of this loss of tissue is not well understood. We recently discovered a copy number variation upstream of matrix metalloproteinase 19 (MMP19) in a large, autosomal dominant pedigree with a congenital malformation of the optic disc called cavitary optic disc anomaly (CODA). Patients with CODA h...

In multiple sclerosis, microstructural damage of normal-appearing brain tissue is an important feature of its pathology. Understanding these mechanisms is vital to help develop neuroprotective strategies. The visual pathway is a key model to study mechanisms of damage and recovery in demyelination. Anterograde trans-synaptic degeneration across the lateral geniculate nuclei has been suggested a...

PURPOSE To investigate optic nerve degeneration associated with CLN3 deficiency in a murine model of juvenile neuronal ceroid lipofuscinosis (Batten disease). METHODS Using light and electron microscopy, the density and diameter of axons and the thickness of myelin in optic nerve were compared between age-matched cln3 knock-out (cln3-/-) and wild-type (129ev/TAC) mice. Western blot analysis w...

The PhD dissertation was carried out at the Eye Pathology Institute, University of Copenhagen, and the Department of Ophthalmology, Rigshospitalet, Copenhagen University Hospital. The aim was to investigate tumours of the optic nerve in a known population. Therefore, we studied all surgically removed tumours of the optic nerve in Denmark during a study period of 25 years. Furthermore, in order ...

PURPOSE Macular schisis or detachment is frequently observed in eyes with optic pits or colobomas. Although spontaneous resolution of the maculopathy has been reported, concurrent changes in the optic nerve coloboma have not. We report three cases of atypical optic nerve colobomas in which dynamic optic nerve changes coincide with the development and subsequent resolution of the associated macu...

Various cysts associated with intraorbital and intracranial portions of the optic nerve have been described. Arachnoid cysts of the optic nerve in association with optic nerve glioma were described by Wolter and McKenney (I964); Holt (I966) described two cases of cysts of the intracranial portion of the optic nerve, and Smith, Hoyt, and Newton (I969) also described cysts of the anterior third o...