Over several years NPL has been developing a calibration service for electron beam radiotherapy. To test this service, a trial calibration of therapy level electron beam ionisation chambers was carried out in 1996, involving fourteen radiotherapy centres supplying a total of eighteen chambers and twelve electrometers. All chambers were either of the NACP 02 (Scanditronix) or Markus (PTW) type. ...

Nucleoplasmin is a histone chaperone that consists of a pentameric N-terminal domain and an unstructured C-terminal tail. The pentameric core domain, a doughnut-like structure with a central pore, is only found in the nucleoplasmin family. Here, we report the first structure of a nucleoplasmin-like domain (NPL) from the unrelated Drosophila protein, FKBP39, and we present evidence that this pro...

AIM To develop specific fluorescent markers for melanoma tumor visualization, which would provide high selectivity and reversible binding pattern, by the use of carbohydrate-recognizing proteins, lectins, combined with the physical ability for imaging deep in the living tissues by utilizing red and near infrared fluorescent properties of specific rare-earth doped nanocrystals (NC). METHODS B1...

Chinese authorities have initiated disposal methods ranging from loans sales to debtfor-equity swaps to resolve the country’s Non-Performing Loans (NPL). NPL securitization, a form of structured finance, tops the list of innovative financing techniques to resolve the remaining USD$73.1 billion of the original USD$170 billion removed from the banking system by Asset Management Companies (AMC), w...

This study aims to analyze the non-performing loan (NPL) in the Regional Development Bank (BPD) in Indonesia and determine the factors that can influence it. This study uses a quantitative approach. The data used in the form of panel data from the financial statements of Regional Development Bank in Indonesia as many as 26 banks 2009-2013. Factors examined its effect on the NPL is a measure of ...

Coronary artery disease (CAD) is the leading cause of death worldwide. Recent genome-wide association studies (GWAS) identified >50 common variants associated with CAD or its complication myocardial infarction (MI), but collectively they account for <20% of heritability, generating a phenomena of "missing heritability". Rare variants with large effects may account for a large portion of missing...

Neuroplasticity (NPL), neuromodulation (NM), and neuroprotection (NPT) are ongoing biophysiological processes that are linked together in sensory systems, the goal being the maintenance of a homeostasis of normal sensory function in the central nervous system. It is hypothesized that when the balance between excitatory - inhibitory action is broken in sensory systems, predominantly due to neuro...

BACKGROUND In an attempt to map the genes predisposing to the common, complex aetiologies of end-stage renal disease (ESRD), we performed a genome-wide scan in 1023 individuals with chronic kidney disease (946 dialysis dependent and 77 with advanced chronic renal failure) from 483 African American families. METHODS The study sample comprised 563 ESRD-affected sibling pairs, with nephropathy a...

PURPOSE Hereditary prostate cancer is an etiologically heterogeneous disease with six susceptibility loci mapped to date. We aimed to describe a collection of high-risk prostate cancer families and assess linkage to multiple markers at four loci: HPC1 (1q24-25), PCaP (1q42.2-43), HPCX (Xq27-28), and CAPB (1p36). EXPERIMENTAL DESIGN Medical record data on 505 affected men in 149 multiply-affec...