BACKGROUND CD44 is a transmembrane receptor found on many different benign and malignant cells. Hyaluronan (HA), a major component of the extracellular matrix, is the primary ligand for CD44 receptors. In cancer cells, HA interaction with CD44 promotes multiple signaling pathways that influence tumor cell progression behaviors in a variety of solid tumors. Increasing evidence indicates that HA ...

BACKGROUND Oral cavity cancer is the eighth most frequent cancer among men in the world. Its incidence varies widely geographically and two-thirds of the incident cases are diagnosed in developing countries. The aim of this study was to present the mortality trends from this cancer for Iranian population during a period of almost a decade, in order to provide update information regarding time t...

OBJECTIVES The association between viral hepatitis (B and C) and oral cavity cancer has been widely debated. This nationwide, population-based cohort study assessed the subsequent risk of oral cavity cancer among patients with chronic viral hepatitis infection. MATERIALS AND METHODS Data were retrieved from insurance claims data of 1,000,000 randomly sampled individuals covered under the Taiw...

AIM The aim of this study is to estimate oral cavity cancer mortality for Iranian population, using Bayesian approach in order to revise this misclassification. BACKGROUND Mortality is a familiar projection to address the burden of cancers, but according to Iranian death registry, about 20% death statistics were still recorded in misclassified categories. PATIENTS AND METHODS We analyzed na...

The oral cavity is not a preferred site for metastasis of distant cancers, accounting for only 1% of all oral cancers. Almost all types of cancers can spread to the oral cavity, and usually are late presentation. Sometimes the oral metastasis may manifest as a benign lesion and may cause challenges in its diagnosis. All patients with oral cavity metastasis diagnosed at King Hussein cancer cente...

BACKGROUND The pupose of this study was to describe variations in incidence and resection rates of patients with oral cavity squamous cell carcinoma (SCC) in Ontario. METHODS All oral cavity SCCs in Ontario between 2003 and 2010 were identified from the Ontario Cancer Registry. Incidence and resection rates along with variations in care were compared by sociodemographic factors and Ontario he...

Abstract—oral cavity cancer also called squamous cell carcinoma is the sixth most frequent overall, it a rising public health concern that spreading across globe. If not detected in earlier stages, might be severe generally, and underlying lesions induce it. Therefore, difficult to locate lesion area if cured its nascent reach stage IV cancer, metastatic stage. To come up with solution, we tend...

PURPOSE High meat consumption, especially red and processed meat consumption is associated with an increased risk of several cancers, however, evidence for oral cavity and oropharynx cancer is limited. Thus, we performed this meta-analysis to determine the association between intakes of total meat, processed meat, red meat, and white meat, and the risk of oral cavity and oropharynx cancer. ME...