Oral delivery of drugs is by far the most preferable route of drug delivery . Oral-rate controlled drug delivery systems have an important area among novel drug delivery system. But these oral sustained release drug delivery systems suffer greatly due to their short gastric residence time/ gastric emptying time. Whereas prolonged gastric residence increases duration of drug release, reduces dru...

Absorption of drugs through the oral cavity was noted as early as 1847 and systemic studies of oral cavity absorption were first reported in 1935 [1]. Since then, substantial effort has been focused on drug absorption from a drug delivery system in a particular region of the oral cavity [2-5]. As a site for drug delivery, the oral cavity offers many advantages over other routes of drug administ...

Oral route is the most common and convenient route for drug delivery, but some drugs are not given by this route. This route is most common problem is low bioavailability .The various challenges faced by the pharmaceutical scientists leads to the improve bioavailibilityty enhance the approach of self emulsifying drug delivery system. It has gained exposure of their ability to increase solubilit...

in the present study, sodium alginate microparticle for oral delivery of furosemide was designed whether the encapsulation into microparticles might improve the oral absorption of this potent loop diuretic. we described preparation of microspheres based on ionotropic gelation method and characterized its physicochemical properties. to acquire an optimum formulation, a generalized regression neu...

Biopolymers are promising materials in the delivery of protein drugs due to their compatibility, degradation behavior, and nontoxic nature on administration. On suitable chemical modification, these polymers can provide better materials for drug delivery systems. Nanostructured drug carriers allow the delivery of not only small-molecule drugs but also of nucleic acids and proteins. The use of b...

delivery of exogenous materials such as nucleic acids, peptides, proteins, and drugs into cells is an important strategy in modern cellular and molecular biology. recently, the development of gene carriers for efficient gene transfer into cells has attracted a great attention. furthermore, lack of effective drug delivery is one of the major problems of cancer chemotherapy. many physical methods...

Chronotherapeutics refers to a treatment method in which in vivo drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. it is also known as pulsatile drug delivery system and it focuses on the release of a drug at particular time and at a particular site in order to maintain constant blood levels of a particular drug. They are...

Good oral health is of important for general health and well-being of the individual. Several innovative drug delivery systems have been developed for the local treatment and prevention of various diseases in the oral cavity. However, currently there are only few optimal systems and many of them are plagued with therapeutic challenges, like low drug efficacy and retention at targeted site of ac...