how to cite this article: derakhshanfar h, modanlookordi m, amini a, shahrami a. a comparative study of the sedative effect of oral midazolam and oral promethazine medication in lumbar puncture. iran j child neurol. 2013 spring;7(2):11-16.   objective lumbar puncture (lp) essentially is a painful and stressful procedure that indicated for diagnosis and therapeutic purposes. one way to reduce th...

Background and Aim: Midazolam is among routine agents used for inducing safe sedation. This study was designed to compare the sedative effect of oral administration of midazolam (Elixir vs Vial) in fearful children during dental treatment. Materials and Methods: A randomized double blind clinical trial was conducted in a cross over style on 20 young fearful aged 3-6 years with Frankl behavio...

A randomised, controlled, crossover trial was designed to assess the safety and effectiveness of oral midazolam sedation for orthodontic extractions. Forty-six ASA physical status I children aged 10-16 years were recruited. Each child required two treatment sessions. Sedation with either oral midazolam 0.5 mg.kg-1 or nitrous oxide in oxygen was used at the first visit, the alternative being use...

OBJECTIVE To assess the efficacy of oral ketamine versus oral midazolam for sedation during laceration repair at a pediatric emergency department. METHODS Children between 1 and 10 years requiring laceration repair were randomly assigned to 2 groups, treated either with oral midazolam (0.7 mg/kg) or with oral ketamine (5 mg/kg).Main outcomes measured were level of pain during local anesthesia...

Ninety day-case or short stay patients were allocated to three groups in a double-blind study. The groups received oral midazolam 15 mg, oral temazepam 20 mg or placebo approximately 1 h before surgery. Midazolam was superior to temazepam regarding anxiolysis, sedation and amnesia, but temazepam was superior to placebo. However, delay in immediate and late recovery occurred significantly more o...

An 8-yr-old boy suffering from an asymptomatic ventricular septal defect was given erythromycin for antibiotic prophylaxis before adenoidectomy. Sixty minutes after premedication with oral midazolam 0.5 mg kg-1 and oral atropine 0.03 mg kg-1, an infusion of erythromycin 400 mg was started. When 200 mg of erythromycin had been infused, the patient lost consciousness, but other vital functions re...

Background: Selecting the best medication for upper GI endoscopy in children is a challenging issue. The goal of this study was to compare the effects of oral and intravenous midazolam for upper gastrointestinal endoscopy (UGIE) on children. Methods: In this randomized clinical trial study conducted in Amirkola Children's Hospital, 110 children were randomly assigned to oral or intravenous g...

INTRODUCTION Midazolam and ketamine are useful for oral premedication in children to allay anxiety. We compared the effects of midazolam with a combination of high- and low-dose ketaminemidazolam as an oral premedication. METHODS This is a randomised, controlled prospective study conducted in 87 children who were scheduled for ophthalmologic surgeries. Group M received oral midazolam 0.5 mg/k...

BACKGROUND To compare oral midazolam (0.5 mg/kg) with oral butorphanol (0.2 mg/kg) as a premedication in 60 pediatric patients with regards to sedation, anxiolysis, rescue analgesic requirement, and recovery profile. MATERIALS AND METHODS In a double blinded study design, 60 pediatric patients belonging to ASA class I and II between the age group of 2-12 years scheduled for elective surgery w...

OBJECTIVE Lumbar puncture (LP) essentially is a painful and stressful procedure, however indicated for diagnosis and therapeutic purposes. One way to reduce the anxiety is to administer an oral premedication. The aim of this study is to compare clinical effects of oral midazolam and oral promethazine in LP. MATERIALS & METHODS This prospective randomized controlled clinical trial study was pe...