introduction: vesicovaginal fistula remains a challenge in surgical therapy. in this study autologous platelet rich plasma and platelet rich fibrin glue were used as a minimally invasive approach for vesicovaginal fistula closure. materials and methods: data including age, parity, iciq-ui (international consultation on incontinence questionnaire-urinary incontinence), iciq-qol (international co...

within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. this has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (cscs), has the capacity to self-renew and form new tumors . it has been proposed that the development of tumors is based exclusiv...

stem cells are naïve or master cells. this means they can transform into special 200 cell types as needed by body, and each of these cells has just one function. stem cells are found in many parts of the human body, although some sources have richer concentrations than others. some excellent sources of stem cells, such as bone marrow, peripheral blood, cord blood, other tissue stem cells and hu...

recently, cell therapy has sparked a revolution in ischemic heart disease that will in the future help clinicians to cure patients. earlier investigations in animal models and clinical trials have suggested that positive paracrine effects such as neoangiogenesis and anti-apoptotic can improve myocardial function. in this regard the royan cell therapy center designed a few trials in collaboratio...

introduction:first, definition the stem cell refers to those cells that are still not clear and are not equipped for a particular task. these cells have proliferative properties and  ability to differentiate into other types of cells have become. this characteristic of stem cells to self-directed has absorbed professional opinion that extensive research is done in this regard. nowadays, stem ce...

liver failure, in an acute or chronic form, is a growing health problem ranking as one of the leading causes of death worldwide. inborn errors of metabolism characterized by defects in hepatic enzymes or other proteins with metabolic functions, such as receptors or transporters accompanied with environmental factors involve etiology and presentation of liver failure. currently, the only establi...

the ability to culture human stem cells long term, and possibly indefinitely, and to control how such cells specialise to form the different tissues of the body offers the possibility of major advances in healthcare. stem cells have been isolated and cultured, but a great deal of research is required to develop cell lines which can generate replacement cells and tissues to treat many diseases.s...

stem/progenitor cell based therapeutic approach in our daily routine clinical practice, has been elusive dream in medical sciences and improvement of stem cell homing as one of major challenges in cell therapy programs, has been considered a promising milestone. it has been proved that stem/progenitor cells exhibit a homing response to injured tissues/organs, mediated by interactions of chemoki...

introduction: we aimed at evaluating the clinical, laboratory and echocardiography effects of intracoronary administration of autologous bone marrow stem cell transplantation in different clinical entities of chronic heart failure (hf) patients.   methods: this procedure was carried out during an interventional study conducted in the cardiology department from jan 2012 to apr 2013. the hf patie...

autoimmune hepatitis is a chronic hepatitis that occurs in children and adults of all ages. diagnosis is based upon characteristic serologic and histologic findings and the exclusion of other forms of chronic liver disease. guidelines issued by the aasld suggest the following diagnostic considerations: the diagnosis should be made in patients with compatible clinical signs, symptoms, and labora...